St. John's Wort vs Wellbutrin

St. John's Wort
(OTC)
Wellbutrin
(Rx)
St. John's Wort is an alternative medication.
Wellbutrin is an antidepressant medication.
Satisfaction Score
?
3.9
Very Satisfied
Satisfaction Score
?
3.4
Moderately Satisfied
Helpfulness
for Depression
5.0
Concern level
1.7
Helpfulness
for Depression
3.2
Concern level
1.7
Approval Date
+ -
Not Available
December 30, 1985
Number of discussions around the web Number of discussions + -
38,971 Discussions
284,593 Discussions
Taken For
+ -
Condition
Number of posts
#1 for Depression
#2 for Anxiety
#5 for Addiction
St. John's Wort is approved for Depression and Anxiety and is mostly mentioned together with these indications.
Condition
Number of posts
#1 for Depression
#2 for Anxiety
#3 for Smoking
#4 for Tiredness
#7 for Weight Loss
#8 for ADHD
#9 for ADD
#10 for Panic Attacks
#11 for Addiction
#12 for OCD
#15 for Panic
#16 for Mood Swings
#17 for Social Anxiety
Wellbutrin is prescribed for Depression and Smoking and is mostly mentioned together with these indications. In addition, our data suggest that it is taken for Anxiety and Tiredness, although it is not approved for these conditions.
Side Effects and Concerns
+ -
St.
Serotonin Syndrome
5
Weight Gain
4
Headaches
4
Mood Swings
4
Irritability
3
Weight Loss
3
Nausea
3
Dizziness
2
Sun Sensitivity
2
Weakness
2
Wel
Seizures
8
Nausea
6
Dizziness
4
Suicidal behavior
3
Psychosis
3
Suicidal Thoughts
2
Paranoia
2
Hair Loss
2
Loss of Appetite
2
Dry Mouth
2
Compare concerns
By:
St. John's Wort
St.
Wellbutrin
Wel
Serotonin Syndrome
St.
Wel
5
0
Weight Gain
St.
Wel
4
0
Headaches
St.
Wel
4
0
Mood Swings
St.
Wel
4
0
Irritability
St.
Wel
3
0
Weight Loss
St.
Wel
3
0
Nausea
St.
Wel
3
6
Dizziness
St.
Wel
2
4
Sun Sensitivity
St.
Wel
2
0
Weakness
St.
Wel
2
0
Seizures
Wel
St.
8
0
Nausea
Wel
St.
6
3
Dizziness
Wel
St.
4
2
Suicidal behavior
Wel
St.
3
0
Psychosis
Wel
St.
3
0
Suicidal Thoughts
Wel
St.
2
0
Paranoia
Wel
St.
2
0
Hair Loss
Wel
St.
2
0
Loss of Appetite
Wel
St.
2
0
Dry Mouth
Wel
St.
2
0
Pregnancy Category (FDA) OpenClose all pregnancy categories
+ -
a b c d x n
Category A
Adequate and well-controllted studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Category X
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Category N
FDA has not classified the drug.
close
Not Available
C Category C
Before taking Wellbutrin during pregnancy, consult your doctor or pharmacists to weigh the risks and benefits.
Alcohol warning
+ -
There may be a negative interaction between St. John's Wort and alcohol.
There may be a negative interaction between Wellbutrin and alcohol.
Method of use
+ -
Oral Drops, Pill
Pill
Dosages
+ -
Capsule: 150 mg, 300 mg, 450 mg, 600 mg, 1000 mg
Tablet: 300 mg, 450 mg
Drops: 25 mg/mL
Tablet: 75 mg, 100 mg
Food Instructions
+ -
No Food Instructions
No Food Instructions
Ingredients
+ -
St. John's Wort
Bupropion Hcl
Drug Interactions
+ -
Interaction between St. John's Wort and Wellbutrin: Undetermined interaction. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice.
Read more about:
St. John's Wort
Read more about:
Wellbutrin
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We found 684 discussions
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Wellbutrin v. St. John's Wort
| Dawn
I suffered from extreme sadness and was prescribed Wellbutrin generic years ago. The side effects were difficult but it was a trade I was willing to take until my pharmacy changed generic manufacturers. The new one was like taking a sugar pill -- back to sadness and crying for no reason. I swapped to the name brand and it worked great until GSK sold the 300XL to Valeant out of Canada. I tried the SL that GSK still manufactures, but the side effects were severe tinnitus and vertigo, as well as some sadness returning. I finally stopped taking it and replaced it with 300 mg. St. John's Wort 3 x day and 5HTP 100 mg 2x day. I cannot tell you when I have been SO happy! The vertigo and tinnitus are gone, but most importantly, I have my joy back -- better than it has been since before I my depression began over 12 years ago. I made the change 2 months ago and I cannot recommend St. John's Wort & 5HTP combo enough!
Tony
February 14, 2015
5-HTP (5-Hydroxytryptophan) is an essential amino acid that is naturally produced in your body from eating a wide variety of foods. The supplement is produced from the seed of a plant native to Africa. 5-HTP is able to cross the blood-brain barrier, where it is broken down by an enzyme and used to produce seratonin.

St. John's Wort increases the amount of seratonin available to the brain by inhibiting its re-uptake and later re-use, so the combination of these two substances (amongst others) i
WTF
September 4, 2014
WTF is HTP?
5HTP
September 4, 2014
What is 5HTP?
July 8, 2014
Never taken it
star
April 14, 2014
what is htp?
Devin
January 3, 2014
Dawn thank you so much for sharing your experience, I have been affraid to try the st. johns wort and 5htp because they say you can get seretonin syndrome. I definitely want to give this a try. Have you found any research about this? Thanks in advance for your help

Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice.
The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you.
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