Methotrexate

Last Update May 3, 2016
Methotrexate is an arthritis medication and a cancer medication.
Uses: Methotrexate is prescribed for RA, Psoriasis and Arthritis and is mostly mentioned together with these indications. In addition, our data suggest that it is taken for Psoriatic Arthritis, although it is not approved for this condition. Read More
Other brands: Trexall, Rheumatrex
Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cance...
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Satisfaction Score
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3.1
5 1 262089
Moderately Satisfied
based on 262,089 conversations around the web
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Last Update May 3, 2016
Satisfaction Score
?
3.1
Moderately Satisfied
based on 262,089 conversations around the web
Share your experience
Share your experience

What people say about Methotrexate

Helpfulness
for RA
2.2
Concern level
1.9
Share your experience
Share your experience
Positive 20,860 "I'm now switching to MTX. I did get initial relief And my Hands still feel much better. But I have had a flare in my feet which was... "Read more positive discussions
Negative 20,813 "I've been off MTX for just over two months ...I was lucky MTX worked well for my RA for 18 months and I think enough must have accumulated to tide me over for a while but its coming back slowly I think.... "Read more negative discussions
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We found 262,089 discussions
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7 years of Peripheral Neuropathy and never made the connection with Plaquenil!
| crcandy
I have been taking Plaquenil along with Methotrexate for about 17 years for rheumatoid arthritis. Around 2009 I began experiencing the symptoms of peripheral neuropathy (DADS with Mag1 antibody) and tests later proved that I did, indeed have this affliction. It has been increasing in severity and I never made the connection with Plaquenil. I thought perhaps it might have been the the result of a vaccination for H1N1 in 2009. Furthermore, I am suffering from chronic itching for almost a year now in my lower back and thighs. None of the treatments prescribed have worked. There has been no conclusive diagnosis.

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| lcook83709
I was recently put on Methotrexate for my psoriasis. Ever since I started to take it, I have had explosive diarrhea within minutes of eating anything. What do I do?

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| Nuzhat Altaf
I was diagnosed with RA 18months ago and since then I am using Methotrexate, it is helping but during first few months I experienced hair fall and then discolouration of the skin,it still is bluish......I look very unhealthy and fatigued....can any one help?
April 3, 2016
I have been using MTX for RA for the last 3 years but started getting Sleep Apnea for the last one year which is worse than RA itself. Only way was to reduce the MTX dose, increase dose, reduce again .....so on.

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Having to temporarily stop methotrexate to have radiation in my face. Any advice on how to handle the withdrawal (Severe headache and can't move)
| Grateful for Methotrexate
I was diagnosed with psoriatic arthritis 10 years ago. I was prescribed methotrexate and have been on methotrexate ever since and of course accompanied by folic acid do today must go hand and hand. I have been so blessed to be able to use methotrexate. Prior to methotrexate I could not move my neck jump down off of something onto the floor without worrying of breaking well thats how it felt. I was 37 when diagnosed and felt like I had the body of a 90 year old. Thankfully methotrexate a lot of my agony. I've always had excellent liver testing, if you're not aware you must test with great liver function or they will not prescribe you methotrexate. I take 8 2.5 milligram tablets once a week (Saturdays). There's been times that I had forgotten to take my dose and would wake up unable to move my neck and a very severe migraine and would need a Demerol shot to be able to eliminate the headache, although I still would struggle on being able to move. Over the years I've had tumors removed from my face 3x to be exact most recently just having them removed was not enough there for now I need radiation. Yesterday I received a message from my Rheumatologist advising me that I must stop taking methotrexate during radiation... I am now devastated if you are taking methotrexate then you understand it takes a minute for it to work again so I have to go through the withdrawals go through the pain and agony of radiation with blisters and so forth in my mouth and then have to start methotrexate again meanwhile migraines mouth pain and not being able to move... God help me... If anyone else has any advice on how to deal with the methotrexate withdrawal please advise me. Thank you

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6mp vs Methotrexate
| Sandys
My 14 year old son has recently been diagnosed with Crohn's Disease. His symptoms were loose stools, blood and mucus in stools, anemia, and skin tags on anus. No pain involved except when trying to take iron pills. He is currently on prednisone which cleared up all loose stool issues. He has more confidence in being able to live his life.
His doctor wants us to decide on 6mp or Methotrexate as treatments. Can anyone give us any insight as to their experiences with either one?

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| Dennis Ernst
After 5 years of self injections of MTX for RA I had to quit the Rheumicade/MTX combo I was using due to liver function decline. I moved to a warm dry climate and stayed off of medications completely. A couple years later I developed homeopathy and lost most of my sensation from waist down. I now have the stinging/electrical shocks in my leg and feet and my feet burn. (especially at night) Lyrica helps a little but does not eliminate the symptoms. I've seen several neurologists and the all tell me it was most likely caused by the MTX.

It may still have been a good choice to use the strong medications and save my joints. I would have likely been in a wheel chair with out the aggressive approach my rheumatologist took.

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| cor
i have osteoarthritis now have psoriatic arthritis. startws methotrexate 7.5 mg last week.
I want to know i f I cantake 30 mg of codeine for the pain before the mtx kicks in

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| cor
can i take a codein 30mg for pain, while taking mtx

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| Teresa64
I take methotrexate one day a week six 2.5 ml pills. It has not stopped my pain. I have been on it for ra for a year. Trying saffron for depression as I do not like Zoloft. Tired of being fat and hurting

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| Ceejay
After being on Methotrexate for several years, I developed tremors on my left side. It's mostly my left hand. I'm not sure what's causing the shakiness. The tremors are slowly getting better since I quit taking methotrexate.

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Facts about Methotrexate

Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. It is also used as a strong anti inflammatory for autoimmune diseases such as rheumatoid arthritis, crohn's, lupus, and psoriasis.
What does Methotrexate look like?
View larger image
Strength : 2.5 mg
Pill imprint : 54323
Color : Yellow
Shape : Round
Attribution
X Pregnancy category (FDA)
Methotrexate is known to cause harm to fetus. Avoid during pregnancy.
ViewClose all pregnancy categories
ALL PREGNANCY CATEGORIES
a b c d x n
Category A
Adequate and well-controllted studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
Category B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Category C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Category D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Category X
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
Category N
FDA has not classified the drug.
close
Alchohol warning on Methotrexate
There may be a negative interaction between Methotrexate and alcohol.
How do I obtain Methotrexate?
Prescription in the USA
What dosages are available?
2.5 mg Tablet, 5 mg Tablet, 7.5 mg Tablet, 10 mg Tablet, 15 mg Tablet, 20 mg Solution, 50 mg Solution, 100 mg Solution, 25 mg/mL Solution
2.5 mg Tablet, 5 mg Tablet, 7.5 mg Tablet, 10 mg Tablet, 15 mg Tablet, 20 mg Solution, 50 mg Solution... Show all
Ingredients
Methotrexate Sodium, Methotrexate, Methotrexate Sodium/Pf
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