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Seroquel vs. Trazodone for Depression

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/ 161,781 posts
Other Names: Quetiapine   Seroquel XR


/ 74,966 posts
Other Names: Desyrel   Oleptro   Molipaxin
Rating: 3.5 out of 5
Based on 161,781 patient discussions on healthcare websites and blogs
Learn more
Rating: 3.5 out of 5
Based on 74,966 patient discussions on healthcare websites and blogs
Learn more
Quetiapine (branded as Seroquel, Ketipinor), is an atypical antipsychotic approved for the treatment of schizophrenia, and bipolar disorder.Annual sales are approximately $5.7 billion worldwide, and $2.9 billion in the United States. The U.S... Read more on Wikipedia
Trazodone (also sold under the brand names Desyrel, Oleptro, Beneficat, Deprax, Desirel, Molipaxin, Thombran, Trazorel, Trialodine, Trittico, and Mesyrel) is an antidepressant of the serot... Read more on Wikipedia
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Help people by sharing experiences you've had with Seroquel or Trazodone - your story could impact others.
Treato My Voice
By Jeff F
September 8, 2014
Jeff F wrote
Trazodone - Leg cramps
Comment on this post
By kelly
August 26, 2014
kelly wrote
ask him to try trazadone
milton  |  February 19, 2015
I been on serquel for two years and came down with sore tongue burning mouth syndrome please help!!!
sam  |  February 13, 2015
Change Doctor please: he's not controlling anything or taking care of you.
J  |  February 8, 2015
Comment on this post
By Monk718
August 21, 2014
Monk718 wrote
Trazadone nightmares
I was on Trazodone for my depression and insomnia. I used to take 100 ~ 150 mg before sleep and about 50%~75% of times I get really bad nightmares but when I lowered to 50mg, I was sleepy enough and when to sleep and no nightmares! I guess lowering the does enough to put u to sleep is the key. I think only 5%~10% will have mild nightmares or weird vivid dream on 50mg. But for me 50mg was the key! Try lowering ur dose to 50mg or enough to make u sleepy. Good luck!. Now, I'm on Ambien and Clonaze
Brian  |  January 9, 2015
I was taking Trazadone as an antidepressant at night but then it started giving me severe night terrrors. I found that the things in my life that were causing me to become depressed were now haunting me in my dreams. I couldn't escape! Instead of being an antidepressant it only reminded me of all the things I hated and my nightmares would haunt me all day long until I fell asleep again and the cycle continues.
I'm sticking to medical marijuana to help me sleep and it always makes me feel happy.
January 5, 2015
I also experienced bad nightmares and decided to stop taking it. I have been able to get normal sleep on lexapro 10mg but I developed tinnitus after starting both at the same time as my Dr. prescribed and this has not resolved since stopping the Trazodone almost 1.5 months ago.
Mac  |  November 13, 2014
I have had the exact same problem :(
moe  |  October 19, 2014
Comment on this post
By Jill Jes
August 7, 2014
Jill Jes wrote
Allergic Reaction to Trazadone
Omg I am so sick from this pill right now. Can not sleep. Diarrhea puking too
December 11, 2014
It ruined my life!!! I would she someone if I could
Lori  |  September 9, 2014
I took the pill for 45 days and felt like a zombie after two days. I got galactorrhea, complete sexual labido cut off, a vaginal discharge for 20 years now the symptoms don't stop. Oh and my hair quit growing on my legs and armpits. Dopamine helps. But gives me a headache. Stay away from anti depressants!!!
Lori  |  September 9, 2014
I didn't have this reaction. If fact, Trazodone has been very helpful for me for sleep with no side effects. I DID have exactly the same experience you are describing when I took my one and only Cymbalta pill for fibromyalgia. Good luck!
Joanne G  |  August 23, 2014
Comment on this post
By lablanche
August 1, 2014
lablanche wrote
haldol vs seroquel
Comment on this post
By Healthy Jack
July 30, 2014
Healthy Jack wrote
acupuncture and back pain
Comment on this post
By Helen Melon
May 27, 2014
Helen Melon wrote
I take this too. Doc put me on 100 mg. I'm 43 and weigh 200 lbs. I've never taken it on an empty stomach, but, the first time couple of times I took it, I actually got up in the middle of the night and did things while I was asleep! (sleep walking) as If I was awake. I'm just glad I didn't decide to go driving! So I cut my dose in half. I don't sleep walk anymore, but I do sleep on average 5-6 hours a night, straight. (Before taking it, I would wake up every 1-2 hours then spend 30 minu
Bryan  |  September 20, 2014
September 15, 2014
I've taken a lot of antidepressants and you should never start on a higher dose (I took a half pill my first night), they can really mess you up because the first few weeks you take them they can be stronger, and you are young. This is why you should never, never take a drug like this without a doctor overseeing you. You took too much, you should have tapered on and seen a doctor. Also, sleeping pills aren't meant for you to be able to walk around and do stuff after, but you're lucky somethi
notcool29  |  August 30, 2014
Hey, I take this medicine. Ive been on it for about a month now. When you take it you have to have food in your stomach, never take it on an empty one it will make you really sick. Also once it kicks in you HAVE to lay down and do not get up. Youll feel your limbs started to get heavy like its hard to even lift your own arm. You do get a very weird kind of heavy floaty feeling. If you stand you can faint, pass out, or black out. The room does spin. I know it can be kinda scary the first time bu
Kayley  |  July 28, 2014
Comment on this post
By Thomas
April 6, 2014
Thomas wrote
Extreme Energy
Comment on this post
February 18, 2014
I have had the same pain in my balls tried elimating cokes, cigs, foods. Nothing has to be Trazadone I take 150mg
Samo  |  February 9, 2015
Trazadone is the heavy duty sleep aid of choice with many psychiatrists b/c it is much better long term compared to ambien and benzodiazepenes but it still has some scary but rare side effects including priapism and arrythmias. If you have sharp pain in your groin or have a sustained, unwanted erection then you need to go to the ER right away and tell them you are taking trazodone.
Me  |  November 28, 2014
Trazodone does cause priapism I am so sorry it was not caught sooner. :( :( :(
Me  |  November 28, 2014
Thanks for the warning about trazodone. i'm sure many people have no problems taking it. I am not one of those. I have had alot of trouble getting to sleep taking it also the next morning I am like a zombie most of the day.I know that it is not for me. I had none of these problems taking ambien.
skylarl mcc  |  November 6, 2014
I checked in to see if there was any new info. I know many have taken this drug with NO reaction. Please realize bad reactions don't happen to everyone. But I want to warn of the POTENTIAL that this could happen. Wish somebody told me!!
SCREWEDFORLIFE  |  October 9, 2014
(god this editor is annoying! If I can't type that much, stop me! Don't let me type 500 characters then drop the last 200!) I stopped taking Ambien because the trazodone seemed to cover the sleeping problem. Now, clonazipam also helps you sleep, and is a longer lasting version of adivan, so I'm going to switch to that and see If I can drop down to just one pill :)
Bryan  |  September 20, 2014
Also, doc had me on Zoloft, Adderal, trazodone, ambien, and adivan, all drugs which, while they don't 'interact' they do entirely opposite things. Adderal 'perks' you up, while Zoloft calms you down. Adivan calms you down quickly, trazodone calms you down (and makes you sleep), ambien helps you fall asleep. So, why would I take Zoloft and adderal?! I stopped taking adderal because it caused me to need more adivan. I stopped taking zoloft cause it caused sexual side effects (being 'too calm
Bryan  |  September 20, 2014
SCREWEDFORLIFE.. You know it was Trazodone because your Urologist said so? You were also told it was a hernia, and cancer. You had 5 operations. Doesn't sound like anyone is really sure what's going on. Search all your drugs for their side effects.
Bryan  |  September 20, 2014
Thank you for sharing your horrible experiences. I will not use this drug
August 24, 2014
I have also been taking trazadone for years and have muscle pain cramps in that area sometimes after I urinate or at random times. I started eating healthier and taking supplements and it got better. I am very sorry for your injury my friend. Some where out there there is a doc that can fix you I hope. Keep looking don't give up !!
August 21, 2014
Patrick Do you work for the drug company ?
Class Action against Trazodone  |  May 31, 2014
I am a 16 year old female, I took Trazadone for the first time a few weeks ago, I wasn't prescribed but I'm diagnosed with insomnia so in desperate need I took 2 of my moms Trazadone pills, being stupid thinking that one wouldn't work but thinking that 2 would. That night I was already extremely stressed out from boy trouble and had very little if not any food in my stomach. About 15 minutes later I noticed the pills started to kick in and I felt like I had to throw up, from then I just decided
Helen Melon  |  May 27, 2014
LISA this is a dire t result of TRAZADONE. Reasearch the net and you will see MANY MANY men are impotent and cannot achieve a erection. When you view the litigation awards that total in millions to tens of millions depending on the case you can be DAM sure that those drug companies fought tooth and nail and LOST. If there was any chance this was just a coincidence you would not see men who have taken the same drug and have same side effect. And if read the warnings this directly states a side e
SCREWEDFORLIFE  |  May 22, 2014
I've been taking trazodone for sleeping. I've been on it for almost four years now. I've never had a bad experience or health issues. Are you sure it's the trazodone that is making you sick?
Lisa  |  May 22, 2014
I KNOW it was trazodone because my Urologist said so. If you take a look at TRAZODONE awards or lawsuits you will see awards for this same exact situation except not as many surgeries that settle in millions to tens of millions. I did my homework before I posted.
SCREWED FOR LIFE  |  May 21, 2014
Tried to say "not cheap" but ran out of space, I guess.
Kate  |  April 23, 2014
Trazodone does indeed cause priapism and this sounds like it could be related. Sadly, the doctor did not figure this out until the nerve damage had been done. For those with nerve pain, please google PEA Pure or Institute for Neuropathic Pain Netherlands. They have stuff in Europe for nerve pain and it can be imported now that the packaging has the proper English supplement facts on it. I have imported it and used it for nerve pain. It does help, but it takes awhile to kick in and it is not che
Kate  |  April 23, 2014
I'm sorry to hear that you have had such pain and that your lifestyle has significantly suffered; however, I do not believe that trazodone has caused any of your problems. They were probably pre-existing and you only noticed them at around the time you took trazodone. I am no expert but it sound like a normal human mistake associating oneproblem with a coincidental (false) "cause".
Patrick  |  March 25, 2014
Why is it that you think that Trazodone caused this? There is nothing in your story that gives a correlation between the two. What is causing your scrot pain?
Hizze  |  March 25, 2014
Comment on this post
By angelajhn
December 17, 2013
angelajhn wrote
Comment on this post
By Girl555
November 26, 2013
Girl555 wrote
does anyone know if it's a smooth transition from Cymbalta (Duloxetine) to Trazodone?
Cymbalta is now out as a generic form and should be more affordable if you want to stick to what is working for you.
JustFYI  |  October 29, 2014
You will need to taper off Cymbalta regardless of what drug you switch to. However, you could start Trazodone right away, I'm on both with no problems. But start taking less of Cymbalta over 2-3 weeks or you will have nauseau, headaches, etc. They call it 'discontinuation syndrome' - you're not addicted but your your brain has trouble adapting to going off it so quickly. I usuually start taking longer and longer time between doses. You can also open the capsules and pour a little bit out e
Vessel323  |  August 30, 2014
Try getting another drug... We are after the FDA to have this drug removed
Class Action against Trazodone  |  May 31, 2014
I have the same swallowing problem with Trazadone but not a breathing problem. I don't eat after taking it and drinking water or milk isn't a problem. Might want to check the dose
Jarbwa23  |  February 7, 2014
Comment on this post
November 10, 2013
PG wrote
Positive experience
trazodone works for my chronic insomnia but with lots of side effects ,eg muscle pain mood swing and nightmares
kerry  |  September 3, 2014
it increase your body mass but its good for sleeping
kerry  |  September 3, 2014
Comment on this post
By alan
November 9, 2013
alan wrote
Quetiapine , and cognitive Impairment
Everyone has different reasons for insomnia and everyone's body reacts differently to meds. Its good to share experiences, but you have to learn for yourself what works best. Sometimes doctors are no help, other than providing access. I hadn't fallen asleep without meds for 15 years and tried most meds mentioned, along with every herb, otc, nonlegal alternatives. I can finally now fall asleep most nights on my own, but wake up in 3-4 hours. But that's progress. Good luck to you all.
Ron  |  August 28, 2014
I have been dealing with MDD and I started taking Seroquel a few weeks ago, 100 mg at bedtime. In addition, I have started taking Effexor; initially 37.5 mg twice a day, just switched to 50mg twice a day.
I feel as though I am just coming out of anesthesia, pretty much the entire day. I can't function normally. My head is in a fog and I don't feel safe driving. This is nuts. How am I supposed to hold down a job?
I am hoping hoping HOPING my body adjusts to these 2 meds, otherwise, I am asking
woolf  |  August 8, 2014
"It really doesn't make sense to me how drugs such as Quetiapine achieve their supposed "anti-psychotic" effects.

My first impression would be that antagonism of 5-HT2a receptors would worsen the negative symptoms of a psychosis by causing confusion and cognitive dissonance.

Also, wouldn't the anticholinergic effects of such drugs contribute to psychosis? Short-term memory impairment is perhaps the main underlying attribute of a psychosis -- wouldn't anticholinergic activity worsen problems
Of course it causes cognitive problems  |  August 3, 2014
There are multiple anti-depressant medications. Consult your prescribing physician on your reactions to your medication. Keeping a journal helps, & will aide in getting you on the right dose or prescription.
June 26, 2014
I've been taking 400-450 mg of Seroquel for over 10 years. I was for
tunate to be treated by a very good Neuro Psychiatrist who has now retired. While taking more than 400mg can cause insomnia. Lower doses of 50-100mg can act as a sleep aid. I function best by taking it all at bedtime along with a sleep aid. When I had to find a new doctor, the first thing he did was screw with my Meds. I should have listened to my instincts, and changed only one med at a time. He changed me too 400mg at nigh
Mer  |  June 8, 2014
I have been on Quetiapine for about 10 years now, it does take a long time to get used to the effects of this drug both good and bad. One thing to remember is, you are used to the way your mind worked before taking the drug, and have to learn how your mind works after taking it. Yes after taking it you will become impaired, it is a very strong tranquilizer. I started on 200ml per day, 25 ml 4 times a day, 100ml at bedtime it took about a year or even 2 before I learned to function while on this
Kellin  |  June 1, 2014
I am feeling the same way, I have been taking 50mg for two weeks a the doctor raised me to 50 mg at bed and 25 mg in the morning. I am fatigued, down, not able to think clearly. This is crazy, I feel that I'm go into depression because of my symptoms.
Rusty  |  March 17, 2014
antipsychotic meds are too much risk to be used off-label
i'm not a comedian  |  January 13, 2014
Its not a sleep aid , you should try something approved for sleep , its a anti psychotic , if your not psychotic don't take it ,
adam  |  January 3, 2014
Comment on this post
By Caroline
September 16, 2013
Caroline wrote
trazadone and swallowing problem
This is normal the first week or so. Just make sure you have plenty of water beside your bed.
craig  |  September 22, 2014
I had trouble swallowing as well, and when you take Trazadone with Caffiene, you could end up in ER with crazy high blood pressure. Ugh
TC  |  August 12, 2014
Comment on this post
By LiveWithPTSD
August 30, 2013
LiveWithPTSD wrote
The light switch
Thanks for the thoughtful post. I was also an eldest. Given my emotional makeup, being very responsible, always the good girl the responsibility of caring for siblings, carrying out chores, attempting to keep peace & unsuccessfully lead my charges to pull their share of the work at a young age took a toll on me too.
I was shy at school & moved every other year. I found relief in theater arts playing characters not me. Later I was discouraged from pursuing theater as a career. Music & books f
mustfindbetterway  |  January 23, 2014
Comment on this post
By When1Was
August 25, 2013
When1Was wrote
Great for gaining weight, bad for sleeping!
Comment on this post
By Maegan
August 1, 2013
Maegan wrote
trazadone & nausea
Comment on this post

What patients are saying about Seroquel vs. Trazodone

6,168 patient discussions from healthcare websites and blogs
things. Seroquel gave me vivid nightmares. Trazadone has...
Trazadone has been the only thing that has helped me. Ambien made me do crazy things. Seroquel gave me vivid nightmares. Trazadone has given me side effects my girlfriend has enjoyed...
trazadone and seroquel both have a side effect of RLS......
...seroquel both have a side effect of RLS... im on 25mg zyprexa at night and it gives me RLS like crazy but I also take .3mg of clonidine with it along with valium...
anti-psychotic drug but many doctors prescibe it for helping...
Quote: I take seroquel too. I'm the same as you trazodone does nothing for me. Seroquel in an anti-psychotic drug but many doctors prescibe it for helping people sleep. Don't worry,...
the same problem with the seroquel. I take Trazadone now,...
...with the seroquel. I take Trazadone now, it also helps with the night terrors...
more depressed. About 6 mg of seroquel has worked better...
...For your sleep problems, have you considered a low dose of seroquel? I could not tolerate trazodone, lunesta, rozerem, or ...and made me more depressed. About 6 mg of seroquel has worked bette...
trazodone and seroquel(low dose) keep me asleep. Are you...
...taking xanax along time? I've been upped to 200mg trazodone now and it has helped. I take 1mg.xanax,that helps ...the trazodone and seroquel(low dose) keep me asleep. Are you...
from trazodone to seroquel last night. Trazodone produced...
...from trazodone to seroquel last night. Trazodone produced tinnitus, so my pdoc ...I slept OK on the seroquel, but morning anxiety seems higher (had morning anxiety with Traz, too). Hopefully,...
at the beginning of the year for insomnia. While it worked...
...too was prescribed Seroquel at the beginning of the year for insomnia. While it worked in the ...I was switched from Seroquel to Trazadone and it is sooo much better. Seroquel has some potentia...
drug, I've had great luck with Seroquel. Trazodone never...
...sleep fine. As far as good sleep drug, I've had great luck with Seroquel. Trazodone never worked for me either. In regards to the tapering, obviously the longer...
I have taken it now for 6 mos. and it works perfect....
...your Doctor about seroquel. I have taken it now for 6 mos. and it works perfect. Another med. ...you blend it with Trazadone (which is also a depression anxiety med. that helps you sleep). Sorry...