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Rebif vs. Tecfidera (BG-12) for MS

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Rebif

Rx
/ 24,995 posts
Other Names: Avonex   Interferon Beta-1a

Tecfidera (BG-12)

Rx
/ 5,612 posts
Rating: 4.5 out of 5
Based on 24,995 patient discussions on healthcare websites and blogs
Learn more
Rating: 3.5 out of 5
Based on 5,612 patient discussions on healthcare websites and blogs
Learn more
Concern level
Top 3 Concerns
Flu Like Symptoms
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Headaches
Flu
Concern level
Top 3 Concerns
Progressive Multifocal Leukoencephalopathy
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Nausea
Itching
See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with Rebif or Tecfidera (BG-12) - your story could impact others.
Treato My Voice
By Ratsy70
August 9, 2014
Ratsy70 wrote
Just started Techfidera
Comment on this post
By Nata
August 2, 2014
Nata wrote
1st day on Tecfidera
I started taking it in May of '14 & no rash or stomach pain. I am sleepy all the time. I could fall asleep tight now. Not sure it's a side effect but was not like this a year ago. Best of luck! I'm here for you XXXX@aol.XXXcom Richie
Richie  |  August 24, 2014
Hang in there...it gets better...
August 20, 2014
Took 2nd dose tonight - Yes, I feel sleepy too. With my first dose this morning - I also turned beet red all over (rash), had some flushing and mild itch. With 2nd dose - My throat feels weird but no flushing and I don't have the rash.
Crystal  |  August 10, 2014
Comment on this post
By Leslie
July 24, 2014
Leslie wrote
Allergic reaction to Tecfidera
I have started getting daily allergic reaction type rashes. Don't seem to get them (at least not as bad) if I take allergy medicine too. Mine tend to last about an hour & then go away. but it is hot, red, itchy...awful when it happens.
November 12, 2014
restarted Tecfidera after a week since my last dose. A few hours after taking first dose, I was completely red all over. Changed clothes into something more loose and sat under a fan. My second dose, a few hours later, I could feel it again and started watching myself turn red again. Drank ice water, and used moist towel to cool my skin. Redness reduced within an hour. Never had it happen when I started it, but maybe being off for a week and then restarting at the full dose was too much
msfireant  |  October 25, 2014
Try taking a low dose aspirin a half hour before each dose, and take it on a full stomach, with peanut butter, or some other healthy fat. It helps with absorption, and prevents flushing. If it continues, try taking Zyrtec once a day. It may just be that Tec isn't for you, in which case, there are other pills, such as Gilenya and Aubagio. But, Tec has less side effects, so I would try to see if the rash will go away, first.
August 17, 2014
I had a rash with red spots on my right leg. I was taking Tecfidera and amoxicllin. My doctor thinks its impetigo, but there is no discharge. I remember I was on medication once and had the same kind of reaction. Not sure if this helps, but thought I would mention it anyway. No flushing but rash on one leg with mild itching. Was told if its get worse to go to dermatology. I have finished the amoxicillin and rash is disappearing.
Unsure  |  August 11, 2014
Comment on this post
By 2
June 11, 2014
2 wrote
My first week
Yikes! Hair loss?!
Nata  |  August 2, 2014
One of the things that can be problematic is taking the Tecfidera while on an antibiotic. Tecfidera is an Immune suppressant So the antibiotics and and Tecfidera don't work together. Tecfidera slows down the immune system and antibiotics speed it up.
Ginger  |  July 18, 2014
Comment on this post
By Verna
May 3, 2014
Verna wrote
Tecfidera and weight loss
1574views
Nice, are now welcoming the comments about its initial decision of the groups of patients, health professionals and others. I suggest you to join that discussion about Tecfidera healthauthoreviews.com
elizaissac  |  September 22, 2014
Comment on this post
By Myachinghead
January 16, 2014
Myachinghead wrote
Migraine
1406views
Comment on this post
By Martha Jones
December 30, 2013
Martha Jones wrote
Nanaforsame@yahoo.com
1383views
Comment on this post
By Vanessa
December 17, 2013
Vanessa wrote
Weight Loss
2316views
Loss of appetie almost immeadiatly. After 2.5 weeks, I need to set a timer to remember to eat.
JHS  |  June 25, 2014
I have been on Tec 2 weeks and am experimenting weight gain w/ hunger.
Lilly  |  April 4, 2014
I started on the tec November 2013, and started dropping a little weight consistently until I stopped it just 2 weeks ago. I would have stayed on it but for the other side effects- debilitating nausea, headaches, tooth and gum lesions and pain and hair loss. When I was asked by someone if I had cancer (because of the weight loss) that was enough for me. I should have known better than to consume cleaning products even if they have "reformulated" it and put it in a capsule. I'm getting tir
Cyndie  |  March 29, 2014
Why Tec? I see no weightloss info on it...
Ramprat  |  February 26, 2014
I've been on Tecfidera about four months now and have lost 20 pounds. While I walk miles and miles every day and eat really well, I haven't really changed diet or exercise.
Kristin  |  January 28, 2014
I've been on Tec for over 3 months now. I've lost about 15lbs w/o dieting or much exercise. Going to see the dr soon
SoccerDad  |  January 26, 2014
Comment on this post
By Linda
December 12, 2013
Linda wrote
Tecfidera
1755views
Feeling the same regarding MS meds. I've been off of Copaxone (injections) for almost 8 years. We just had 2 car accidents and I'm so fearful of more flareups so I began Tecfidera the other day. Yes, the flushing, itchy deal is a nuisance but it's the effect of being tired that I'm having a hard time with. Not at all happy about that! It's bad enough when MS symptoms create a sluggish feeling, now that coupled with this med, stinks.
Nata  |  August 2, 2014
One of the things that can be problematic is taking the Tecfidera while on an antibiotic. Tecfidera is an Immune suppressant So the antibiotics and and Tecfidera don't work together. Tecfidera weakens the immune system and antibiotics strengthen the immune system.

I would highly advise that if you have any kind of infection and are about to start a regime of Tecfidera consult your doctor and do not start until you are infection free.
Ginger  |  July 18, 2014
I have been on Tecifedera for 8 months now and it has been a blessing. I have not had a flareup since on it whereas before it was everyother month. The flushing can be avoided by taking an aspirin with it...it really is a great medication! I recomend switching to it.
Megan  |  May 31, 2014
Comment on this post
By Marcia
September 5, 2013
Marcia wrote
Tecfidera
1884views
Pam I also am experiencing extreme fatigue. I am not sure if it's just my MS or if the drug is making it worse. I feel like my arms and legs have weights attached to them.
Ann  |  March 11, 2014
I recently switched from Copaxone, after 10 years. I had no injection sites left. I have been on Tecfidera about 7 months. My recent MRI scans is stable. I still flush, intermittently, several hours after meals. Benadryl handles it well. The major side effect that I have is extreme fatigue. This is different than my normal MS fatigue. I am trying to stick with it to see if after time, it subsides. Hope this helps!
Pam  |  January 6, 2014
Hi Marcia, I do not take Tecfidera but am considering it. I have taken copaxone for over ten yrs. now and have had some flares with optic neuritis, heavy legs with difficulty walking and some fat destruction in my legs where shots are done but Copaxone seems to be working and I feel very stable. I do try to stay out of the sun and to keep my stress as low as possible (read Bible for this every p.m.). I am looking into Tecfidera as I would like to stop taking shots daily. jane
jane  |  September 16, 2013
Comment on this post
By Cheryl Baker
August 22, 2013
Cheryl Baker wrote
I've been on Tecfidera for about 3 months...
2809views
I have been taking it for about 3 weeks now and the only side effects I have experience is itching all over and little rash like areas. And for some reason I have been extremely hungry and I don't know if it could be coming from me taking this medicine. Do any one else have an increase of appetite??
Lashun  |  November 26, 2014
I've been on Tecfidera for about a year and after an 8 year remission stretch of Crohn's or Colitus (they couldn't concretely say which one I have) it's BACK!!! Asacol, a treatment for Crohn's, isn't working so now I have ot get off of Tecfidera and will likely go on Azathioprine to get Crohn's under control. This is bad, really bad folks. Azathioprine is very dangerous and it may not help my MS, but the Crohn's is getting so bad I have to let it take precidence over MS. I see online that Tecfi
Tecifidera and Crohn's?  |  September 8, 2014
Trisha, I hope you are still hanging in there. The simplest thing for me made all the difference in the "furnace effect". I read somewhere else that several people took aspirin an hour before Tecfedra. The flushing and heat is so minor now that I do that. I have a lot of hope hanging on this medicine as well. Let's hang on together!
Anne Marie  |  August 25, 2014
It does get better, Trisha. For me it is an every once-in-a-while side effect. It only happens maybe once every 2-3 months.
Cheryl Baker  |  June 10, 2014
I just started low dose 120 mg Tecfedra. I'm just now 3d week getting the sweats.
I'm getting real horrible sweats ( flushing ). I haven't even begun the 240 mg dose &
I'm bout ready to throw in the towel. I'm so misrable. I haven't been able to stay on
anything, this was my really big hope! Does this constant heat go away? Feels like Im
A furnace on the inside. I get dripping wet. Just begun on third week too. I thought this time
I'd make it. Anyone else have this problem ?
Trisha  |  June 10, 2014
I've been on the Tecfidera for a month and now am having unusually heavy cycle that came 2weeks early.
Michelle  |  May 16, 2014
I have been on it for 6 months and have not had those issues.
Pam  |  January 6, 2014
Comment on this post

What patients are saying about Rebif vs. Tecfidera (BG-12)

475 patient discussions from healthcare websites and blogs
Rebif (abnormal liver function) and to BG-12. He said that...
...office visit with my neurologist this morning. He plans to switch me from Rebif (abnormal liver function) and to BG-12. He said that BG-12 will be available in May....
since I have done fairly well on Rebif. Nervous... but...
...everywhere. After 8 years of Rebif shots, I'm down to two ...I'm still nervous about switching to Tecfidera, since I have done fairly well on Rebif. Nervous... but mostly excited. I'm...
I have been on Rebif for 6 years and did well except...
...from Rebif to Tecfidera ...Hi everyone. I have been on Rebif for 6 years and did well except for my body ...shots anymore so my doctor is switching me to Tecfidera. It seems like I...
minimal side effects, occasional flushing and small GI upset...
...was on Rebif for almost 10 ...I have been on Tecfidera for 14 days and I am so glad I switched.  I have had minimal side effects, occasional flushing and small GI upset, but neither is painful....
I never felt better being off of rebif. No more extra...
...was on copaxone then rebif and developed an interferon ...tested for it? I never felt better being off of rebif. No more extra ...are or are not a good candidate for Tecfidera. Probiot...
or Avonex. I am seriousley considering stopping Tecfidera...
...I don't have the flushing or GI problems but do get very dizzy and lightheaded when I stand quickly. Never had these problems with Rebif or Avonex. I am seriousley considering stopping Tecfidera. I...
for rrms. I was also on Rebif and switched to Tecfidera....
...neuro because there are several pills now for rrms. I was also on Rebif and switched to Tecfidera. Best of luck to...
Tec in May (was on Rebif before) and the Tecfidera forum...
...info here! I just started Tec in May (was on Rebif before) and the Tecfidera forum is a great place for your fiancé to get tips or...
actually) about switching from rebif to tecfidera. i've...
i'm gonna talk to my neuro (tomorrow actually) about switching from rebif to tecfidera. i've been on the 'bif for 13 years. (lol at 'bif) i know the knots hurt. i...
She currently is taking Rebif and doing quite well with...
...Sclerosis Drug BG-12 Has anybody heard of ...had an appointment with her neuro today and is looking to put her on BG-12. She currently is taking Rebif and doing quite well with the only si...
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