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Prednisone vs. Wellbutrin for Inflammation

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/ 438,694 posts


/ 226,256 posts
Other Names: Bupropion   Wellbutrin XL   Zyban   Wellbutrin SR   Budeprion
Rating: 3.5 out of 5
Based on 438,694 patient discussions on healthcare websites and blogs
Learn more
Based on 226,256 patient discussions on healthcare websites and blogs
Learn more
Prednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressive drug drug. It is used to treat certain inflammatory diseases and (at higher doses) some types of cancer, but has significant adverse effects. Because it ... Read more on Wikipedia
Bupropion ( marketed as Wellbutrin, Zyban, Voxra, Budeprion, or Aplenzin and formerly known as amfebutamone) is an atypical antidepressant and smoking cessation aid. The drug is a non-tricyclic antidepressant and di... Read more on Wikipedia
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Weight Gain
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Mood Swings
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Help people by sharing experiences you've had with Prednisone or Wellbutrin - your story could impact others.
Treato My Voice
By Darren
February 18, 2015
Darren wrote
depersonalization with bupropion
Comment on this post
By jaqueline
February 14, 2015
jaqueline wrote
euphoric prednisone
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By db
February 4, 2015
db wrote
wellbutrin and slurred speech
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By Brunhilde
January 24, 2015
Brunhilde wrote
Slow release prednisone (Lodotra)
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By Kiley
January 23, 2015
Kiley wrote
Wellbutrin made my Vulvodynia go away
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By Sammy
October 17, 2014
Sammy wrote
Decongestants have similar anti depressive effects as Wellbutrin in some people.
Comment on this post
By Worried
October 2, 2014
Worried wrote
Fetzima and Menstrual Cycle
I am on my 5th day of taking the Fetzima Initial starter pack. I am also late with my cycle. I've been cramping for a week, yet no bleeding. I am now almost a week late now, but, I'm not always on a 28 day cycle. I used to work for an OB-GYN practice, and if someone of child bearing years reached day 33 and had not started their cycle, we'd have them take a pregnancy test. If you haven't been sexually active, I'd be inclined to relate this symptom to the Fetzima. I want to say on drugs.com th
Similar issue  |  December 19, 2014
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By Antlion
September 9, 2014
Antlion wrote
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By Mark
August 28, 2014
Mark wrote
Prendisone for Gouty Arthritus
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By Audrey
August 9, 2014
Audrey wrote
UTI and prednisone
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By Anna
July 24, 2014
Anna wrote
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By Dan T.
July 15, 2014
Dan T. wrote
auto-immune hepatitis and medications
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By June
July 9, 2014
June wrote
Wellbutrin generic
Comment on this post
By Adro
June 20, 2014
Adro wrote
Pred vs. Ulceris
Comment on this post
By John Barclay
June 10, 2014
John Barclay wrote
Prednisone 40mg 5-day dosage gave immediate relief from my anxiety at nighttime and libido went up.
So weird! Got Prednisone for some allergic dermatitis and they told me not to take it near bed time because it makes you wired. Not the case with me! I still take it in the morning but by night time I actually am tired and sleep without needing to take my anxiety medicine. I've been on Xanax for over a year to help me sleep at night. Its great! I hope for the short time I am on it it will just get me into a better sleep pattern!
Rachel  |  August 14, 2014
Comment on this post
By Denise
May 19, 2014
Denise wrote
Librax/Bupropion combination
Comment on this post
By Rameda
April 18, 2014
Rameda wrote
Predisone and swollen leg
Comment on this post
By sea
March 3, 2014
sea wrote
possible side effects
Comment on this post
By Shelly
January 21, 2014
Shelly wrote
Now you know why its called "Roid rage"
Jenn  |  December 5, 2014
High doses of prednisone have had the 'speed' effect on me. I felt great with lots of energy and happy but I couldn't shut up. It wasn't a problem for me, I liked it. My dose that day was probably 30 mg. Now I stay at 20 or under for inflammation of my bronchial tubes and don't take it if it isn't absolutely necessary. I'm also not good with 'weaning myself off' of it, as the doctor said to do but I have no side affects besides a bit of face swelling after a couple of days on it. Keep your dosa
Jean  |  August 27, 2014
hya ,I have been on prednisone for 3 months and ,when I was on 40mg a ady I was talking all the time ,doing my sisters head in ,it was a side effect for me ,also very aggressive and personalty changed dramatically ,just started swelling in face neck top of arms ,and distended abdomen ,I have thyroid eye disese and thyrotoxicosis also on immune surpressants so hopefully after 6 weeks of these a can come down off steroids
deb  |  June 15, 2014
I was orig put on hydrocortisone, my joints all went bad, I had confused brain and memory loss. Then they put me on prednisolone, god I was in a rage all the time. At the end of 3 weeks my brain felt like it was going to burst. I'm being told I need steroids to live. But since I've taken them I'm just egsisting. I have trouble walking, my feet are so painful and my brain is mush.
Willow  |  March 30, 2014
I was put prednisone for wheezing. I am 46. On day 4. My heart
Rate is going down to as low as 52. I have dry mouth and
I'm talking more than normal. I have anxiety normally
And I'm freaking out about my heart rate. I can't confirm that its the
Prednisone but my heart rate is typically fast.
I am afraid my heart is going to just stop.
Marnie46  |  March 29, 2014
Prednisone had a similar effect on me. I became a lot more violent and easily irritated. I found that normal things would set me off and make me rageful. My mood was almost bipolar. It does go away once off the med for about a week or so. The mental changes are not permanent at all, but they are definitely the result of Prednisone.
March 24, 2014
Yes, definitely. This has happened to me as well as my sister, especially when the steroid (prednisone) levels are high. Talking more like if your really have too much caffeine in your system, also constant urination (more at night) and lastly sudden changes in mood.
Mark  |  March 12, 2014
YES! I am in the VERY same boat with my dad! I wish I had seen your post sooner.
mickilynn  |  February 22, 2014
Comment on this post
By Lighthouse
January 20, 2014
Lighthouse wrote
Prednisone and Suicidal
Sorry for your loss. I understand why Stanford had been reluctant to add a Psychiatrist to the team, as medical costs seem to be sky rocking. When will it ever be enough? Prednisone effects are wide and varied and should not be ascertained just by a chart or list but by the individual. Sad or not..I feel this diagnosis can only be done by the patient themselves. Prednisone is not a dangerous drug in itself. However, I realize my logic is like saying a Gun is not a danger in itself either. But h
FreudsOtherBrother  |  February 25, 2015
I'm so sorry for your lost. I was on 90 mg Prednizone and was in so much pain fr my decease. I was so depress and moody and was always have negative thoughts. It was the worst of the worst time. Now i m on 10mg every other day. I feel great. Thank God I m still alive.
thanhthanh  |  July 9, 2014
i was on prednisone 40mg i feel awful and low mood , cry every day i want kill myself not worth my life i hate steriod affect my heart fast beat and ectopic beat terrible but steriod reduce 5mg start feel better
yvonne  |  April 15, 2014
I was on 80 mg a day at the peak and it made me quite angry and violent. I was never near suicide but it definitely messed with my mind. However, I found that this effect ended about a week after I stopped taking it, and I did not have any serious withdrawal problems.
March 24, 2014
Yes, "speedy and talkative" is a common effect. The psychotic effects can kick in on higher doses. My husband was on 160 when he became psychotic the first time and 90 the second. What is important is that depression can occur while coming off, even tapering the correct way. Doctors know about that. What they need to also know is how to treat those who do show extreme lability. What you can do is make sure your doctors are aware.
Lighthouse  |  January 23, 2014
I'm so sorry to hear about your experience. I am wondering if my mom will get like that when she stops the prednisone. While on it, she is speedy and talkative and child-like acting. I'm wondering if it will be like a crash effect when it gets out of her system. Was your husband ever speedy and talkative on it?
shelly  |  January 21, 2014
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By CareBear2000
January 15, 2014
CareBear2000 wrote
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By may
January 14, 2014
may wrote
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By Willie DeJarnette
December 3, 2013
Willie DeJarnette wrote
Zoloft Weight Loss
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By Dawn
November 22, 2013
Dawn wrote
Wellbutrin v. St. John's Wort
5-HTP (5-Hydroxytryptophan) is an essential amino acid that is naturally produced in your body from eating a wide variety of foods. The supplement is produced from the seed of a plant native to Africa. 5-HTP is able to cross the blood-brain barrier, where it is broken down by an enzyme and used to produce seratonin.

St. John's Wort increases the amount of seratonin available to the brain by inhibiting its re-uptake and later re-use, so the combination of these two substances (amongst others) i
Tony  |  February 14, 2015
WTF  |  September 4, 2014
What is 5HTP?
5HTP  |  September 4, 2014
Never taken it
July 8, 2014
what is htp?
star  |  April 14, 2014
Dawn thank you so much for sharing your experience, I have been affraid to try the st. johns wort and 5htp because they say you can get seretonin syndrome. I definitely want to give this a try. Have you found any research about this? Thanks in advance for your help
Devin  |  January 3, 2014
Comment on this post
By Tracy
November 17, 2013
Tracy wrote
On Prednisolone
Comment on this post
By Jean
November 7, 2013
Jean wrote
trunkel obesity caused by prednisone
I am currently in Anatomy and Physiology II at Northwest Florida State College and it sounds like you might have Cushing's Disease. General signs and symptoms of this includes fat redistribution (Truncal Obesity) and weight gain. However, it is treatable because all it is, is an overproduction of the hormone Cortisol. With that being said, just tell your family physician that you need a lab for your Cortisol/Corticosterone levels. Hope this helps!!
Malcolm Griffith  |  April 11, 2014
Comment on this post
By danny
November 4, 2013
danny wrote
be careful
Same here - went on it once, (Budeprion XL) 3 weeks later got costochronitis... went on it a year later, and got the same result. After that, I had issues digesting gluten. I had no issues prior or took any medication prior.
Wes  |  August 7, 2014
Comment on this post
By Natalie
October 31, 2013
Natalie wrote
Wellbutrin / Menstrual Cycle
Wellbutrin also exacerbated my menstrual cycle.
October 1, 2014
I started taking Wellbutrin XL 300mg about a year ago. I'm quiet diligent in tracking my menstrual cycle and noticed after taking it for a few weeks that my period never came. I got the bloated feeling, cramps, swallon breasts but no period. Two weeks late, my period finally arrived. Since then I've had no problems at all though. My period is right on track every month. Guess it was just my body/hormone getting used to the medication.
Caroline  |  January 8, 2014
Comment on this post
By Nicole
October 14, 2013
Nicole wrote
Wellbutrin and Orgasms (the good and the bad)
As a man, I have noticed that I cannot have an erection. I can still masturbate and orgasm but not get hard. I am also starting Trazodone. I know it's for sleep problems; but does that aid in erections? Let me know.Thanks.
Siegfried  |  October 5, 2014
OMG I thought it was just me. Was on it previously and noticed an increase in libido and orgasm strength. Went off it for 2 years and encountered very weak and hars to reach climax. Back on it again now and they are amazing again!
Jeannie  |  September 23, 2014
Hi Nicole, my names Jonathan. I know the feeling you are talking about it's become a real problem for me, but for me the weak orgasm or absence of the "peak" climax is ocuring for me while being on bupropion 300 xl. It was such a problem for me that I completely lost interest in even trying to have sexual relations or masturbation because it was too much work for very little results. The trade of was that it was working well on the depression and I noticed more energy, better outlook on things
Jonathan  |  June 18, 2014
It's okay, it's coming back but for me it was great before I stopped
Been there  |  March 27, 2014
Comment on this post
September 19, 2013
JADE wrote
ulcer colitis and prednisone
I have wasted lots of money in doctor offices and at the pharmacy, not to mention the time spent not feeling very well.
The thing that helped me the most has being visiting the acupuncturist . She also prescribed Chinese herbs for joint pain, etc. And she has provided help with the right foods to eat at the right time, and more importantly the foods to AVOID. I did not know that sugar causes pain. It causes swelling and therefore pain. I can not have one spoonful of flavored yogurt w
Mary McCrae  |  August 3, 2014
I had the same symptoms for months before being diagnosed with PMR. Predisone is the only medication that will help this disease. 2 years later and I'm still on a daily dose of 5.5mg the good news is that predisone is cheap and has long term data on it and low doses are pretty safe. I am going to acupuncture to try and get off the predisone. good luck.
Poly myalgia rheumatic  |  June 20, 2014
Comment on this post
By Beveerly Johnson
September 19, 2013
Beveerly Johnson wrote
Trunkel obesity caused by prednisone
yes taking too much prednisolone can raise your cortisol levels causing obesity ie, cushings disease and un fortunately the only way to get rid of it is exercise, and also metabolic tests to check insulin levels hopes this helps
marie  |  December 3, 2013
Comment on this post
By Eva Cagle
September 14, 2013
Eva Cagle wrote
Wellbutrin and arthritis
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By Emtmelissa
September 14, 2013
Emtmelissa wrote
Another positive for Wellbutrin
Has anyone gained weight on this medication
lucy  |  September 8, 2014
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By Patient like you
September 13, 2013
Patient like you wrote
Comment on this post
By Mockingbird813
September 2, 2013
Mockingbird813 wrote
Risperdal flat affect
I would try to find a good acupuncturist and tell your story to them. You might be surprised by the pressure points that can help with emotions, meaning too much manic, or not enough. It would be worth it to find a good acupuncturist , many ailments are treatable, with swift results.
Mary McCrae  |  August 3, 2014
Comment on this post
By Mag
August 20, 2013
Mag wrote
Temporal Lobe Epilepsy from Welbutrin?
Comment on this post
By Jarvis Johnson
August 14, 2013
Jarvis Johnson wrote
Swollen feet
Same thing with me yesterday afternoon it started to swell. This morning they're so swollen I'm in pain walking, sitting, raising them and even tried to ace bandage the fluid. Nothing has worked. Tinkling in lower legs began an hour ago. Might have to go to ER except I don't have insurance
Lynn  |  September 16, 2014
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By terry
terry wrote
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What patients are saying about Prednisone vs. Wellbutrin

415 patient discussions from healthcare websites and blogs
effexor--but Wellbutrin was awful. prednisone makes many...
...had has made me manic--tho I have never taken effexor--but Wellbutrin was awful. prednisone makes many...
The Prednisone caused weight increase which was...
...comments on this combination? The Prednisone caused weight increase which was bad for my joints changed my eating habits but did not help.Took diet pills for a month felt much better but I know...
last year, had to take prednisone and a steroid because of...
...acute dystonic reaction from abilify several years ...and possibly photosensitivity or lupus-like reaction happen when I was taking Wellbutrin and Effexor last year, had to take prednisone and a...
down. I feel so much better on the Wellbutrin and the 10mg...
...the Remicade sooner. I will mention it again. They moved it up one week from 8 weeks to 7 weeks. Not much help there. ...I feel so much better on the Wellbutrin and the 10mg of prednisone. I...
body and ended up on Prednesone (sp?) to stop the allergic...
...over my body and ended up on Prednesone (sp?) to stop the ...just one of the Wellbutrin pills and got hives within 30 min. Anyway, ...dissappointed but had to go off the Wellbutrin, and have...
last year, had to take prednisone and a steroid because...
...acute dystonic reaction from abilify several ...year and possibly photosensitivity or lupus-like reaction happen when I was taking Wellbutrin and Effexor last year, had to take prednisone and a ...
Pred. It certainly made me weak and sleepless. Also, the...
...attacks, are from the Pred. It certainly made me weak and sleepless. Also, the weakness ...tests say. How long have you taken Wellbutrin? It can make ...someone who's taken Wellbutrin for ...
and it has helped me quite a bit with depression....
I take Wellburtin and it has helped me quite a bit ...anything to do with the Wellbutrin.. The one good thing about ...need to) I still had some prednisone weight gain and the...
Prednisone: the only sustenance That keeps this Easter...
...To wag my bloated hand you-ward ...children, To know my aches and creaks and ...Sythroid, Floxnase, Albuterol, Flovent, Wellbutrin, Pro- Zac, Prednisone: the only sustenance That keeps th...
I did when I got off of prednisone) I feel like I need...
...Wellbutrin initiall side effects? What I mean is I have the slightly increased heart rate, and everytime I try to start this, I always wish I didn't. I get scared that it's going to give me a heart...