I started plaquenil 400 mg 4 weeks ago. The nightmares started 1 week after starting and are getting more and more vivid, real and terrifying. Typically nightmares don't bother me but as a survivor of severe domestic abuse with PTSD, my nightmares decided to relive that part of my life every time I close my eyes. I hadn't had any nightmares or relapses of the PTSD for 3 years until starting this med. The lupus symptoms have improved with the combination of methotrexate I had been on and I'm not getting pneumonia all the time like I was on the TNF inhibitors. However starting to rethink this med if I'm going to be going to bed to these dreams every night. My doctor told me how important the treatment is being I'm 32 and my heart is being affected now. Do they ever get better??