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Oxycodone vs. Zoloft for Pain

Change usage

Oxycodone

Rx
/ 140,768 posts
Other Names: Oxycontin   Roxicodone   Oxyir   Oxynorm   Endone

Zoloft

Rx
/ 283,953 posts
Other Names: Sertraline   Lustral
Rating: 2 out of 5
Based on 140,768 patient discussions on healthcare websites and blogs
Learn more
Rating:
Based on 283,953 patient discussions on healthcare websites and blogs
Learn more
Oxycodone (OxyContin and other brand names) is an opioid analgesic medication synthesized from opium-derived thebaine. It was developed in 1916 in Germany, as one of several new semi-synthetic opioids in an attempt to improve on the existing opioid... Read more on Wikipedia
Sertraline hydrochloride (brand names Zoloft and Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depressi... Read more on Wikipedia
Concern level
Top 3 Concerns
Nausea
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Vomiting
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Nausea
Dizzy
See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with Oxycodone or Zoloft - your story could impact others.
Treato My Voice
By irene
July 29, 2014
irene wrote
stealing
Comment on this post
By Randy
July 27, 2014
Randy wrote
Diabetic Symptoms with Zoloft
Comment on this post
By char
June 27, 2014
char wrote
grand mal seizure and oxycodone
Oxycodon will not cause seizures on its own when decreasing dosage or even when in full blown withrawel. You will feel like complete shit but unless there is an underlying health issue opiates/opioids are usually fairly safe to come off of. The addictive a substances that have dangerious withdrawels and can cause seizures if not properly tapered off are benzos (i.e. Xanax) and alchohol.
Lemon  |  July 25, 2014
Had you recently decreased your oxycodone dose (by even a small amount) or missed a dose (even if you didn't immediately feel any ill effects after the skipped dose)?
I had a seizure a few years ago after taking less of my xanax than usual for a couple days in a row. At first they couldn't find a cause for the episode, but ultimately chalked it up a change in the amount of xanax in my system. After years on high daily doses of xanax, my body took that as the norm and carried out its other funct
HH  |  July 4, 2014
Comment on this post
By kellie
June 13, 2014
kellie wrote
self injury
Comment on this post
By user
April 8, 2014
user wrote
Zoloft
1722views
Comment on this post
By corrupted_jes
March 27, 2014
corrupted_jes wrote
Zoloft
1461views
Comment on this post
By RecallZydus
March 13, 2014
RecallZydus wrote
All Zydus generics
I just had the same experience with Zydus Labs 15 mg oxycodone. Panic, stomach issues, dilated pupils, heart palpitations. That's after only taking those for 3 days. I took them back to doctor, he wrote another prescription for the balance of unused meds. I called Zydus Labs and FDA, placed a adverse affect form with both. Now I have KVK brand, so much better.
T.B.  |  July 4, 2014
Comment on this post
By irishscottish
February 14, 2014
irishscottish wrote
celexa
1110views
Comment on this post
By Madison
January 8, 2014
Madison wrote
Zoloft Weightloss and Abilify
1395views
I started taking Zoloft about 3 weeks ago. I have been suffering with severe, medical depression, social anxiety and feelings of dread. I have good reasons to be depressed, as my Mom died of cancer 4 years ago, and I was diagnosed with Ovarian Cancer 2 years ago. Now I'm post menopausal at 39 and just can't cope. Immediately after taking Zoloft I began to feel good. Depression had become physically debilitating and I gained a lot I weight. I have also noticed a lack of desire for food, and have
Beana  |  July 4, 2014
I also have to take Diflucan/flucanozole occaisionally while taking Zoloft...never any problems.
debra  |  March 31, 2014
Zoloft saved my life. Outside of my wonderful husband it is the thing in life I am most grateful for. Much better than Prozac where I always felt medicated.It is not for everyone but if doc recommends it, I would try it. Just pay attention and give it some time and if you have any side effects do not wait to address them...do it immediately.
debra  |  March 31, 2014
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By Kay terfinko
December 20, 2013
Kay terfinko wrote
Zoloft and gallbladder
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By captclap
December 7, 2013
captclap wrote
exalgo
Exalgo is very strong but it takes a few days to get up to full strength in the body. I take 2 oxycodone 10mg every 4 hours but after being prescribed exalgo 16mg I just take one in the morning and I'm good all day. Only need the oxy when break through pain gets tough.
Rob  |  February 17, 2014
16' rods??? wow, you must be an avatar creature to have 16 foot rods in your spine.
Rob  |  February 17, 2014
Comment on this post
By Willie DeJarnette
December 3, 2013
Willie DeJarnette wrote
Zoloft Weight Loss
2341views
Comment on this post
By agnes
November 30, 2013
agnes wrote
heart pounding
I find I get way more severe reaction to caffeine when I am on Zoloft. Have to drink caffeine free coke!
Otherwise I get a racing heart, exactly like a panic attack. Took me ages to figure out, I thought they were panic attacks!
Frankie  |  June 10, 2014
Its suppose to slow your heart down...
April 28, 2014
Comment on this post
By Deidre Ferrentino
November 3, 2013
Deidre Ferrentino wrote
Lortab 10/500
Comment on this post
By LisaB
October 27, 2013
LisaB wrote
Zoloft and neck stiffness
i am taking Mirtazapine and sometimes Lorazepam and sometimes xanax and I too get these stiff necks and just does not subside - i have had them for the last 2 months now - any advice?
rr98  |  July 14, 2014
Same thing with me I have horrible neck pain
And stiffness and a headache and I also take zoloft
Megan  |  June 27, 2014
I take Zoloft and had horrible neck pain from out of no where.. Wonder if it's from that my dr prescribed my flexerol for it.
May 28, 2014
Same thing, neck pain for months now. Diagnosed for RA now, and prescribed Methortexrate.
mike  |  May 6, 2014
Yes, I also take Zoloft and have bad neck and back stiffness. It does seem to subside after awhile. Try heat and stretches...good luck.
Cheryl  |  February 18, 2014
Comment on this post
By Nia
September 8, 2013
Nia wrote
Suicidal
Comment on this post
By kwissy
September 6, 2013
kwissy wrote
shaky hands
Hi, I have a 12 yr old son...just hope you get better and that u have some people in your life who love u as much as I love my son. If u don't, keep looking, you will find people who care. Good luck, and if the Zoloft feels bad for you, tell your dr. I'll be hoping you are ok. ;-))
Jaipria  |  June 22, 2014
Im glad Zoloft has helped with your depression however it didnt help with mine. I would talk with your doctor about the shaky hands. I stopped taking Zoloft awhile ago and I still have shaky hands from it.
jp  |  June 8, 2014
Comment on this post
By trav
August 11, 2013
trav wrote
oxycodone/sleep apnea
To Mary, sorry to hear about your story. It sounds like your daughter might have coincidentally developed a psychotic condition e.g. schizophrenia independently of the oxycodone. Not that I am a big fan of oxy, but if you get fixated on oxy as the cause of your daughter's psychosis, no one will take you seriously as opioids simply do not cause chronic psychosis (they can cause acute delirium). Hope things get better for you and your daughter.
Dave  |  June 24, 2014
It would be nice to have some kind of warning about comment length. Over half my last comment got cut off and lost, and nothing told me I had gone over any character limit. All that work, and pain, to type it out, and gone!
Jacob  |  April 23, 2014
That's right. All opioids can cause central sleep apnea, do to their respiratory depression effect. All meds of any kind can cause various adverse reactions in some people. But different people do react differently to different drugs. It's a matter of you and your doctor deciding if the benefits outweigh the risks.

Although opioids do tend to give me apnea, I need the pain control, and so I accept the adverse effects. I take morphine, with oxy for breakthrough, because the methadone I used t
Jacob  |  April 23, 2014
My daughter was on Oxy (presecribed by an incompetent GP) and after little over a year & Many pills later she became Psychotic from the meds. It was the only medicine she was taking & I watched the progression of the psychosis. I don't care what the drug companies Phony Reports say. Oxy Can Cause Psychosis---and it doesn't wear Off (even after the meds are stopped--we are over a year now!) and there Is No Cure. I hate the pharmaceutical companies they ruined my daughter's life--and her entire f
Mary  |  April 21, 2014
Also, I started out on 5 pain meds....down to just this one. And after being seen by a Maximized Living Chiropractor (beginning 11/2013) I have decreased the oxycodone by 30 pills a month - 3 months ago.
3 spinal fusions  |  April 8, 2014
I am 45, female and have been on oxycodone for 9 years and do not have sleep apnea. The sleep study verified that. sorry, but meds don't have the same effect on everyone.
3 spinal fusions  |  April 8, 2014
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What patients are saying about Oxycodone vs. Zoloft

258 patient discussions from healthcare websites and blogs
at 0400. The Oxycodone helps with my pain and the Zoloft...
...me to try Melatonin for sleep problems I decided to give it a try. WOW. When I wake up at night I'm able to get back to sleep quickly. But the best part is I'm finally able to sleep in. After g...
I'm gonna take 45 mg of oxycodone. Is the combination...
...to take 25 mg of Zoloft tonight for depression and tonight I'm gonna take 45 mg of oxycodone. ...
that after snorting oxycontin one can possibly go back to...
...came home with prescriptions for oxycontin, oxycodone and zoloft. he's up all night every night again. does anyone think that after snorting oxycontin one c...
taken it for the past 2 days cause i keep getting a rash...
...been taking the zoloft (50mg) for about a week and haven't taken it for the past 2 days cause i keep getting...
much oxycodone I need each day isn't working. But I won't...
...bad stuff happen. 100 mg zoloft as much oxycodone I need each day isn't working. But I won't really....
it would. Im back on regular oxycodone 20mg 2-3x a day,...
...thought it would. Im back on regular oxycodone 20mg 2-3x a day, ...your Dr that you are experiencing anxiety with it, and ...Maybe increase your paxil? Im taking zoloft which works wonders fo...
hours per day. Taking Oxycodone to combat the pain....
...200 mg of Zoloft for about four ...I hurt the worse the depression. I still hurt 22-23 hours per day. Taking Oxycodone to combat the p...
oxycodone for back pain and now I am taking tramadol....
...taken oxycodone for back pain and now ...I am being treated for depression and Zoloft shouldn't be. Taken with tramadol. I am taking 400 mg of tramadol a da...
about 35mg of oxycodone/hydrocodone everyday. Tomorrow...
...Going cold turkey and starting Antidepressent Swim was prescribed zoloft (sertraline) and will start taking ...swim has been taking about 35mg of oxycodone/hydrocodone everyday. Tomorrow swim...
ODd bfore but it was on oxycodon. i weight 90ish pounds and...
...so i havnt taken my meds [zoloft an antidepressant] in a month and well something happened to make me feel ...me OD i have ODd bfore but it was on oxycodon. i weight 90ish pounds and im 5 ...
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