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/ 167,817 posts
Other Names: Rheumatrex   Trexall
Methotrexate (International Nonproprietary Name) , abbreviated MTX and formerly known as amethopterin, is an antimetabolit... Read more on Wikipedia
Based on 167,817 patient discussions on healthcare websites and blogs. Learn more
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Methotrexate Top Concerns

Based on 167,817 patient discussions on healthcare websites and blogs
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By Sandy
September 13, 2014
Sandy wrote
Methotrexate and Diverticulitis
I have been on Methotrexate for about 6 months because of RA. I had upper and lower endoscopies prior to taking meds. No signs of Diverticulitis. As a matter of fact, I was not even sure what that disease was at that time. However, I was soon educated. I have had two severe bouts of Diverticulitis about 6 weeks apart. I was treated with Cipro. I just had foot surgery when the second bout occurred. On the up side, I was so sick from the Diverticulitis that I forgot my foot pain. I have asked my doctor to take me off methotrexate because I would rather deal with the joint pain than Diverticulitis.
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By Sandra
September 10, 2014
Sandra wrote
I have been taking MTX for the past 4 years for Psoriasis and Psoriatic Arthritus and whilst taking it orally it made me feel extremely sick. I have changed now to injecting the MTX and find that there is now no sick feeling. However I have been suffering with warts on all different parts of my body.
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By Saeed
March 29, 2014
Saeed wrote
Methotrexate really working for me
I went for my monthly blood tests 2 days ago and I would like to post the result for the benefit of other users of methotrexate. As per the results my liver and kidney are doing fine and the C-Reactive Protein ( a measure of inflammation) went down from 34 to 10 (less than 5 being normal) after 4 weekly doses of methotrexate of 20mg per week. I am feeling much better these days and using Celebrex 200mg only twice a week. My White blood cell count however still in the high normal range. I will post the result of my blood tests next month again.
hi i been on methotrate for 7 months now , only side effect i have had is heavy periods , they work really well for me almost back to normal.
julie  |  January 6, 2015
Thanks for the updates saeed, how are you getting on after more than six months?my doc wants me to go on it.
tristan  |  December 11, 2014
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By Saeed
March 17, 2014
Saeed wrote
I started methotrexate 20 mg per week three weeks ago to treat my very high inflammation due to psoriatic arthritis. I was really scared after reading all the stories about possible side effects of methotrexate. And in fact I delayed the treatment for about one month. But I am happy to report that so far I do not have any side effects. I take methotrexate on Saturday and split the dose in two. I take 4 tablets in the morning and 4 at night. I also take the folic acid 2 mg the other 6 days. Before starting methotrexate I could note function properly without taking Celebrex 200 mg every day. Now I am taking Celebrex every other day. I will go for my blood test at the end of this months (after 5 doses) to see if the inflammation is gone down or not. I will post the result on this post again.
I've been taking methotextrate injections for lupus & it's made a HUGE difference in my pain levels. I can now walk up & down stairs without my cane! Awesome medication!
January 30, 2015
I've started two weeks ago. Glad to hear that...
June 14, 2014
I am feeling the same way.
Laurel  |  June 4, 2014
I too am reluctant to begin treatment with Methotrexate...for same reason....scared of side effects...glad to read someone else feels the same!
Jean M  |  April 16, 2014
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By Saeed
February 28, 2014
Saeed wrote
I have pain and stiffness in most of my body in the morning for over 5 years. Recently I started taking Celebrex 200 mg one a day at night. I feel normal in the morning now and go to work and play table tennis in the evening with no problem. By the way I am 57 years old male and live in Surrey BC Canada. My RA Specialist sent for some blood test and my C-Reactive Protein result came out as 16, 18, 20 and recently 34mg/l. My RA Specialist wants me to go on Methotrexate 20mg per week. Reading about the side effects of Methotrexate, I am really scared to use it. My RA Specialist asked me to continue using Celebrex with Methotrexate. I am reluctant to start Methotrexate and wondering if there is any safe drug to reduce inflammation? Or may be any alternative medicine.
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By Elizabeth
August 29, 2013
Elizabeth wrote
Methorexate 100mg

I have been diagnose with ectopic pregnancy at 6 weeks my OBYGN decide to put me and methotrexate 100mg because of my weight and height and my HCG level was 8800. After my first shot I felt very hot and my lower left lip was drumpping like crazy. Anyway I was given another dosage on day 4 of which I began feeling tired, sleepy and three days later I felt sever pain which last for about two hours. I stated bleeding on day eight with mild pain in my lower abdomen and left side. Also my vagina has become very sore because of itching, could this itching be some sort of infection?
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By Txbetty
August 13, 2013
Txbetty wrote
Itching all over...Celebrex, Methotrexate, Hydrochlorothiazide the cause???
I have been taking 200 mg of Celebrex for OA for over 4 years with good results, 12.5 mg of HCTZ for over two years, and about two months ago began taking 5 tabs 2.5 mg of Methotrexate for RA. All was fine until a week ago when I started itching all over, head to ankles. The ONLY places I do not itch are my hands and feet. I feel like I am being tortured!! Benedryl did nothing to help so I am now taking RX antihistamie Amlodipine Besylate 5 mg four times a day and prednisone daily, plus my RA doctor immediately took me off the MTX and switched out the Celebrex and HCTZ for other meds (I am also going through bottles of Gold Bond Medicated lotion like crazy!). He is not sure which is the culprit so is trying this route before reintroducing the Celebrex and HCTZ. Has anyone else had the issue of whole body itching with any of these meds? I know any one of these drugs may have itching as an issue but with the timing I am leaning toward the methotrexate. Or is there something that can trigger an allergic reaction like what I am having? I know I have to be careful about being in the sun; my family went to the beach about a month ago but I would think a reaction would have been sooner if sun was the cause. Any ideas? Help!!
It is probably from your pain meds. Narcotics have the same effect on me.
March 5, 2015
I am also on methotrexate injection and itch all over. I also take folic acid and several other medications but the itching didn't start until I started opioid pain killers. I don't think its one or the other I think it is the combination of all three. My doctor has told me to take antihistamines when it is no longer tolerable.
Sue  |  December 31, 2014
CELEBREX does contain sulfa. If you are allergic to sulfa, that could be cause of rash

December 2, 2014
The problem could actually be Fibromyalgia, which many people with RA suffer from.
Susanne Deumig  |  April 21, 2014
Txbetty and Hal, Like both of you, I have been on Celebrex for at least a year. I also take HCTZ 12.5 mg and started Methotrexate two months ago. I did have itching all over like you described, Txbetty, and I figured out that it was simply the particular brand of folic acid I was taking. It's been a long time since you wrote your post, but I happened to see it and wanted to comment. I assume you are taking folic acid if you are still on MTX; if you are still itching then it is something to
Lily  |  February 1, 2014
I have been on Celebrex for over a year and had fantastic results. I suffered pain in my neck and shoulders due to arthritis. Celebrex was like a miracle for me. I was going to physio for the pain, which did not good. Now after being pain free for one year I have been experiencing extreme itchiness all over my body. It feels like something crawling in my scalp, eyebrows, nose and beard. Then it feels like something biting me and there is nothing there and I have no bites . Yikes.
Hal  |  August 25, 2013
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What patients are saying about Methotrexate

167,817 patient discussions from healthcare websites and blogs
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