General Satisfaction score :
Treato analyzes billions of patient discussions to understand what patients are saying about their experience with regard to their treatments, diseases and side effects. Treato algorithmically identifies patients' positive experiences about medications within their Web posts, for example acne that cleared up, high blood pressure that was reduced, a certain drug that "worked", and so forth. Treato aggregates all of these discussions to calculate how many positive patient posts each medication received, relative to other drugs. Note that positive patient posts about medications are always aggregated in relation to a specific condition, since the same medication may be used for more than one condition.
See what millions of patients are saying
Can we help?
Join now!

Methotrexate

Ask a question
201,582
Discussions
Ask a question
Other names: Trexall, Rheumatrex
Prescribing mode: Rx
*Off Label
Methotrexate (International Nonproprietary Name) , abbreviated MTX and formerly known as amethopterin, is an antimetabolit...
Read on Wikipedia
7 / 10
Satisfaction
?
Based on medical discussions around the web
Rate it yourself
Your rating:
Your rating has been added!
Methotrexate for RA
201,582 conversations around the web about Methotrexate to help you make a decision
We analyzed what people said about Methotrexate and compared it to other RA medications
Ask a question
7 / 10
Satisfaction
?
Based on medical discussions around the web
content loaded dynamically

What people say about Methotrexate

Positive 15,262
Negative 11,668
We found 201,475 discussions
Milmas
Just want to know if anybody knows what side effects can occur with methotrexate and estroven. I also use Enbrel for RA.

Sandy
Methotrexate and Diverticulitis
I have been on Methotrexate for about 6 months because of RA. I had upper and lower endoscopies prior to taking meds. No signs of Diverticulitis. As a matter of fact, I was not even sure what that disease was at that time. However, I was soon educated. I have had two severe bouts of Diverticulitis about 6 weeks apart. I was treated with Cipro. I just had foot surgery when the second bout occurred. On the up side, I was so sick from the Diverticulitis that I forgot my foot pain. I have asked my doctor to take me off methotrexate because I would rather deal with the joint pain than Diverticulitis.

Sandra
Methotrexate
I have been taking MTX for the past 4 years for Psoriasis and Psoriatic Arthritus and whilst taking it orally it made me feel extremely sick. I have changed now to injecting the MTX and find that there is now no sick feeling. However I have been suffering with warts on all different parts of my body.

Saeed
Methotrexate really working for me
I went for my monthly blood tests 2 days ago and I would like to post the result for the benefit of other users of methotrexate. As per the results my liver and kidney are doing fine and the C-Reactive Protein ( a measure of inflammation) went down from 34 to 10 (less than 5 being normal) after 4 weekly doses of methotrexate of 20mg per week. I am feeling much better these days and using Celebrex 200mg only twice a week. My White blood cell count however still in the high normal range. I will post the result of my blood tests next month again.
julie
January 6, 2015
hi i been on methotrate for 7 months now , only side effect i have had is heavy periods , they work really well for me almost back to normal.
tristan
December 11, 2014
Thanks for the updates saeed, how are you getting on after more than six months?my doc wants me to go on it.

Saeed
Methotrexate
I started methotrexate 20 mg per week three weeks ago to treat my very high inflammation due to psoriatic arthritis. I was really scared after reading all the stories about possible side effects of methotrexate. And in fact I delayed the treatment for about one month. But I am happy to report that so far I do not have any side effects. I take methotrexate on Saturday and split the dose in two. I take 4 tablets in the morning and 4 at night. I also take the folic acid 2 mg the other 6 days. Before starting methotrexate I could note function properly without taking Celebrex 200 mg every day. Now I am taking Celebrex every other day. I will go for my blood test at the end of this months (after 5 doses) to see if the inflammation is gone down or not. I will post the result on this post again.
January 30, 2015
I've been taking methotextrate injections for lupus & it's made a HUGE difference in my pain levels. I can now walk up & down stairs without my cane! Awesome medication!
June 14, 2014
I've started two weeks ago. Glad to hear that...
Laurel
June 4, 2014
I am feeling the same way.
Jean M
April 16, 2014
I too am reluctant to begin treatment with Methotrexate...for same reason....scared of side effects...glad to read someone else feels the same!

Saeed
Inflammation
I have pain and stiffness in most of my body in the morning for over 5 years. Recently I started taking Celebrex 200 mg one a day at night. I feel normal in the morning now and go to work and play table tennis in the evening with no problem. By the way I am 57 years old male and live in Surrey BC Canada. My RA Specialist sent for some blood test and my C-Reactive Protein result came out as 16, 18, 20 and recently 34mg/l. My RA Specialist wants me to go on Methotrexate 20mg per week. Reading about the side effects of Methotrexate, I am really scared to use it. My RA Specialist asked me to continue using Celebrex with Methotrexate. I am reluctant to start Methotrexate and wondering if there is any safe drug to reduce inflammation? Or may be any alternative medicine.

Elizabeth
Methorexate 100mg
Hi,

I have been diagnose with ectopic pregnancy at 6 weeks my OBYGN decide to put me and methotrexate 100mg because of my weight and height and my HCG level was 8800. After my first shot I felt very hot and my lower left lip was drumpping like crazy. Anyway I was given another dosage on day 4 of which I began feeling tired, sleepy and three days later I felt sever pain which last for about two hours. I stated bleeding on day eight with mild pain in my lower abdomen and left side. Also my vagina has become very sore because of itching, could this itching be some sort of infection?

Txbetty
Itching all over...Celebrex, Methotrexate, Hydrochlorothiazide the cause???
I have been taking 200 mg of Celebrex for OA for over 4 years with good results, 12.5 mg of HCTZ for over two years, and about two months ago began taking 5 tabs 2.5 mg of Methotrexate for RA. All was fine until a week ago when I started itching all over, head to ankles. The ONLY places I do not itch are my hands and feet. I feel like I am being tortured!! Benedryl did nothing to help so I am now taking RX antihistamie Amlodipine Besylate 5 mg four times a day and prednisone daily, plus my RA doctor immediately took me off the MTX and switched out the Celebrex and HCTZ for other meds (I am also going through bottles of Gold Bond Medicated lotion like crazy!). He is not sure which is the culprit so is trying this route before reintroducing the Celebrex and HCTZ. Has anyone else had the issue of whole body itching with any of these meds? I know any one of these drugs may have itching as an issue but with the timing I am leaning toward the methotrexate. Or is there something that can trigger an allergic reaction like what I am having? I know I have to be careful about being in the sun; my family went to the beach about a month ago but I would think a reaction would have been sooner if sun was the cause. Any ideas? Help!!
March 5, 2015
It is probably from your pain meds. Narcotics have the same effect on me.
Sue
December 31, 2014
I am also on methotrexate injection and itch all over. I also take folic acid and several other medications but the itching didn't start until I started opioid pain killers. I don't think its one or the other I think it is the combination of all three. My doctor has told me to take antihistamines when it is no longer tolerable.
December 2, 2014
CELEBREX does contain sulfa. If you are allergic to sulfa, that could be cause of rash

Susanne Deumig
April 21, 2014
The problem could actually be Fibromyalgia, which many people with RA suffer from.
Lily
February 1, 2014
Txbetty and Hal, Like both of you, I have been on Celebrex for at least a year. I also take HCTZ 12.5 mg and started Methotrexate two months ago. I did have itching all over like you described, Txbetty, and I figured out that it was simply the particular brand of folic acid I was taking. It's been a long time since you wrote your post, but I happened to see it and wanted to comment. I assume you are taking folic acid if you are still on MTX; if you are still itching then it is something to
Hal
August 25, 2013
I have been on Celebrex for over a year and had fantastic results. I suffered pain in my neck and shoulders due to arthritis. Celebrex was like a miracle for me. I was going to physio for the pain, which did not good. Now after being pain free for one year I have been experiencing extreme itchiness all over my body. It feels like something crawling in my scalp, eyebrows, nose and beard. Then it feels like something biting me and there is nothing there and I have no bites . Yikes.

the start of december third week of mtx and still no change...
" "

got bc,they treat cancer with methotrexate,and sle if they...
" ...and was on methotrexate for 5yrs and got bc,they treat cancer with methotrexate,and sle... "

Patient concerns with Methotrexate

We found 201,475 discussions
Milmas
Just want to know if anybody knows what side effects can occur with methotrexate and estroven. I also use Enbrel for RA.

Sandy
Methotrexate and Diverticulitis
I have been on Methotrexate for about 6 months because of RA. I had upper and lower endoscopies prior to taking meds. No signs of Diverticulitis. As a matter of fact, I was not even sure what that disease was at that time. However, I was soon educated. I have had two severe bouts of Diverticulitis about 6 weeks apart. I was treated with Cipro. I just had foot surgery when the second bout occurred. On the up side, I was so sick from the Diverticulitis that I forgot my foot pain. I have asked my doctor to take me off methotrexate because I would rather deal with the joint pain than Diverticulitis.

Sandra
Methotrexate
I have been taking MTX for the past 4 years for Psoriasis and Psoriatic Arthritus and whilst taking it orally it made me feel extremely sick. I have changed now to injecting the MTX and find that there is now no sick feeling. However I have been suffering with warts on all different parts of my body.

Saeed
Methotrexate really working for me
I went for my monthly blood tests 2 days ago and I would like to post the result for the benefit of other users of methotrexate. As per the results my liver and kidney are doing fine and the C-Reactive Protein ( a measure of inflammation) went down from 34 to 10 (less than 5 being normal) after 4 weekly doses of methotrexate of 20mg per week. I am feeling much better these days and using Celebrex 200mg only twice a week. My White blood cell count however still in the high normal range. I will post the result of my blood tests next month again.
julie
January 6, 2015
hi i been on methotrate for 7 months now , only side effect i have had is heavy periods , they work really well for me almost back to normal.
tristan
December 11, 2014
Thanks for the updates saeed, how are you getting on after more than six months?my doc wants me to go on it.

Saeed
Methotrexate
I started methotrexate 20 mg per week three weeks ago to treat my very high inflammation due to psoriatic arthritis. I was really scared after reading all the stories about possible side effects of methotrexate. And in fact I delayed the treatment for about one month. But I am happy to report that so far I do not have any side effects. I take methotrexate on Saturday and split the dose in two. I take 4 tablets in the morning and 4 at night. I also take the folic acid 2 mg the other 6 days. Before starting methotrexate I could note function properly without taking Celebrex 200 mg every day. Now I am taking Celebrex every other day. I will go for my blood test at the end of this months (after 5 doses) to see if the inflammation is gone down or not. I will post the result on this post again.
January 30, 2015
I've been taking methotextrate injections for lupus & it's made a HUGE difference in my pain levels. I can now walk up & down stairs without my cane! Awesome medication!
June 14, 2014
I've started two weeks ago. Glad to hear that...
Laurel
June 4, 2014
I am feeling the same way.
Jean M
April 16, 2014
I too am reluctant to begin treatment with Methotrexate...for same reason....scared of side effects...glad to read someone else feels the same!

Saeed
Inflammation
I have pain and stiffness in most of my body in the morning for over 5 years. Recently I started taking Celebrex 200 mg one a day at night. I feel normal in the morning now and go to work and play table tennis in the evening with no problem. By the way I am 57 years old male and live in Surrey BC Canada. My RA Specialist sent for some blood test and my C-Reactive Protein result came out as 16, 18, 20 and recently 34mg/l. My RA Specialist wants me to go on Methotrexate 20mg per week. Reading about the side effects of Methotrexate, I am really scared to use it. My RA Specialist asked me to continue using Celebrex with Methotrexate. I am reluctant to start Methotrexate and wondering if there is any safe drug to reduce inflammation? Or may be any alternative medicine.

Elizabeth
Methorexate 100mg
Hi,

I have been diagnose with ectopic pregnancy at 6 weeks my OBYGN decide to put me and methotrexate 100mg because of my weight and height and my HCG level was 8800. After my first shot I felt very hot and my lower left lip was drumpping like crazy. Anyway I was given another dosage on day 4 of which I began feeling tired, sleepy and three days later I felt sever pain which last for about two hours. I stated bleeding on day eight with mild pain in my lower abdomen and left side. Also my vagina has become very sore because of itching, could this itching be some sort of infection?

Txbetty
Itching all over...Celebrex, Methotrexate, Hydrochlorothiazide the cause???
I have been taking 200 mg of Celebrex for OA for over 4 years with good results, 12.5 mg of HCTZ for over two years, and about two months ago began taking 5 tabs 2.5 mg of Methotrexate for RA. All was fine until a week ago when I started itching all over, head to ankles. The ONLY places I do not itch are my hands and feet. I feel like I am being tortured!! Benedryl did nothing to help so I am now taking RX antihistamie Amlodipine Besylate 5 mg four times a day and prednisone daily, plus my RA doctor immediately took me off the MTX and switched out the Celebrex and HCTZ for other meds (I am also going through bottles of Gold Bond Medicated lotion like crazy!). He is not sure which is the culprit so is trying this route before reintroducing the Celebrex and HCTZ. Has anyone else had the issue of whole body itching with any of these meds? I know any one of these drugs may have itching as an issue but with the timing I am leaning toward the methotrexate. Or is there something that can trigger an allergic reaction like what I am having? I know I have to be careful about being in the sun; my family went to the beach about a month ago but I would think a reaction would have been sooner if sun was the cause. Any ideas? Help!!
March 5, 2015
It is probably from your pain meds. Narcotics have the same effect on me.
Sue
December 31, 2014
I am also on methotrexate injection and itch all over. I also take folic acid and several other medications but the itching didn't start until I started opioid pain killers. I don't think its one or the other I think it is the combination of all three. My doctor has told me to take antihistamines when it is no longer tolerable.
December 2, 2014
CELEBREX does contain sulfa. If you are allergic to sulfa, that could be cause of rash

Susanne Deumig
April 21, 2014
The problem could actually be Fibromyalgia, which many people with RA suffer from.
Lily
February 1, 2014
Txbetty and Hal, Like both of you, I have been on Celebrex for at least a year. I also take HCTZ 12.5 mg and started Methotrexate two months ago. I did have itching all over like you described, Txbetty, and I figured out that it was simply the particular brand of folic acid I was taking. It's been a long time since you wrote your post, but I happened to see it and wanted to comment. I assume you are taking folic acid if you are still on MTX; if you are still itching then it is something to
Hal
August 25, 2013
I have been on Celebrex for over a year and had fantastic results. I suffered pain in my neck and shoulders due to arthritis. Celebrex was like a miracle for me. I was going to physio for the pain, which did not good. Now after being pain free for one year I have been experiencing extreme itchiness all over my body. It feels like something crawling in my scalp, eyebrows, nose and beard. Then it feels like something biting me and there is nothing there and I have no bites . Yikes.

the start of december third week of mtx and still no change...
" "

got bc,they treat cancer with methotrexate,and sle if they...
" ...and was on methotrexate for 5yrs and got bc,they treat cancer with methotrexate,and sle... "

Compare Methotrexate to other medications

RA medications
Methotrexate
201,582 discussions
Taken for: RA, Arthritis, Psoriasis, Inflammation*, Lupus*
Other names: Trexall, Rheumatrex, Methotrexate (Anti-Rheumatic), Folex PFS
Method of use:
Prescribing mode: Rx
*Off Label
7
Satisfaction
Prednisone
458,092 discussions
Taken for: Inflammation, Allergies, Ulcerative Colitis, RA, Crohn's Disease
Other names: Deltasone, Meticorten, Liquid Pred, Orasone, Prednisone Intensol
Method of use:
Prescribing mode: Rx
7
Satisfaction
Enbrel
93,914 discussions
Taken for: RA, Psoriasis, Arthritis, Inflammation, Psoriatic Arthritis
Method of use: Injection
Prescribing mode: Rx
8
Satisfaction
Humira
124,213 discussions
Taken for: Crohn's Disease, RA, Psoriasis, Inflammation, Arthritis
Method of use: Injection
Prescribing mode: Rx
8
Satisfaction
Remicade
101,767 discussions
Taken for: Crohn's Disease, Ulcerative Colitis, RA, Inflammation, Arthritis
Method of use: Injection
Prescribing mode: Rx
8
Satisfaction
Plaquenil
59,891 discussions
Taken for: Lupus, Pain, RA, Sjogren's Syndrome, Joint Pain
Other names: Quineprox
Method of use: Pill
Prescribing mode: Rx
6
Satisfaction
Arava
8,581 discussions
Taken for: RA, Inflammation
Other names: Leflunomide
Method of use: Pill
Prescribing mode: Rx
7
Satisfaction
Imuran
46,525 discussions
Taken for: Crohn's Disease*, Ulcerative Colitis*, Inflammation*, Lupus*, IBD*
Other names: Azathioprine, Azasan, Azamun, Azathioprine Sodium
Method of use: Injection, Pill
Prescribing mode: Rx
*Off Label
5
Satisfaction
Sulfasalazine
13,945 discussions
Taken for: RA, Ulcerative Colitis, Arthritis, Inflammation, Crohn's Disease*
Other names: Azulfidine, Sulfazine, Azulfidine EN-Tabs, Sulfazine EC
Method of use: Pill
Prescribing mode: Rx
*Off Label
6
Satisfaction
Celebrex
46,451 discussions
Taken for: Pain, Arthritis, Inflammation, Swelling, RA
Other names: Celecoxib, Celcox
Method of use: Pill
Prescribing mode: Rx
6
Satisfaction

Your Saved Posts ()

Back to Signup