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Glipizide vs. Metformin for Diabetes

Change usage

Glipizide

Rx
/ 6,303 posts
Other Names: Glucotrol   Glucotrol XL

Metformin

Rx
/ 384,876 posts
Other Names: Glucophage   Glumetza   Glucophage XR   Fortamet   Metforming
Rating: 3 out of 5
Based on 6,303 patient discussions on healthcare websites and blogs
Learn more
Rating: 4 out of 5
Based on 384,876 patient discussions on healthcare websites and blogs
Learn more
Glipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation. The structure on the R2 group is a much larger cyclo... Read more on Wikipedia
Metformin (International Nonproprietary Name, pronounced , originally sold as Glucophage) is an oral antidiabetic drug in the biguanide class. It is the first-line treatment drug of choice for the treatment of diabetes mellitus type 2, in particu... Read more on Wikipedia
Concern level
Top 3 Concerns
Hypoglycemia
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Weight Loss
Weight Gain
Concern level
Top 3 Concerns
Nausea
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Hypoglycemia
Diarrhea
See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with Glipizide or Metformin - your story could impact others.
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By metformin experimenter
August 2, 2014
metformin experimenter wrote
meformin & thyroid (TSH)
Comment on this post
By Hemm
July 11, 2014
Hemm wrote
Metformin
I also take Metformin 500mg and my A1c was also 6.1 and I was told I'm pre-diabetic.I need yo lose weight and I believe that will take care of the whole pill taking thing.I have changed my the way I eat.
MKeith  |  September 21, 2014
Comment on this post
By Karenbc
April 29, 2014
Karenbc wrote
Metformin and Aleve
I was taking two pills a day and had to stop because I was constantly hungry. Maybe you nee to cut back to one.
Stephanie  |  August 23, 2014
I have been taking Metformin for about 4 yrs now, and just the thought of swallowing the pill makes me wanna gag. I hate the taste of it on my tongue. I also take it while I eat... at least before my last bite, so that I know that it will go down. Another thing I noticed is, when I forget to take it for a day, I get gassy when I start it again. I thought it was just me.
misteek  |  July 22, 2014
I HAVE BEEN TAKING 500 MGS OF METFORUM A DAY FOR 10 YEARS. AT FIRST IT MADE ME SICK. VERY SICK TO MY STOMACH. BUT I STARTED EATING SOMETHING FIRST BEFORE I TOOK MY PILL. I FOUND THAT WAS THE THING TO DO. NOW I JUST TAKE IT AND I DONT ET SICK ANYMORE
ALICE  |  June 29, 2014
There is a time release Metformin which helped me with some reactions. Dr. almost didn't mention it though. Tammy
June 23, 2014
I have the runs all day. If I bend down 2 tie my shoe, underwear change. My stomach is upset all the time. I'm afraid to pass gas, I might shard myself.
Tee  |  June 17, 2014
My doctor prescribed 1000 mg Metformin twice a day. I took just the first evening and second day morning and evening. I had a total throw up the whole evening dinner and little lunch grapefruit. I stopped taking that. I just went back to my old pill Glyb/Metformin 2.5/500. I watch what I eat now in order to take just half of it once daily. If I have a big dinner, I had to take the whole pill. I try to eat less meats and more vegetables. My sis just warned me on the long taking Metformin
Oli  |  June 17, 2014
I am light headed on the Metformin too. Just started it a couple of weeks ago.
JohnMc  |  May 26, 2014
Comment on this post
By Angel's Mom
January 23, 2014
Angel's Mom wrote
Metformin & Bad Breath
1288views
People with Chronic halitosis have no idea of how bad it is, when it is “on” or “off” and when it is really acutely tragic. Once the source is identified, a reasonable person will take every necessary action they know to do to remedy it or reduce it to a bearable level by all means necessary. I am a reasonable man, but unfortunately, i could not solve a problem i don't know how to fix.
I had suffered with it for over 5 years (correlating to my time on Metformin) and never knew the height, dept
DrMike76  |  August 13, 2014
Comment on this post
By Bob
December 5, 2013
Bob wrote
Type 2 Diabetes, Metformin and Lovastatin
1315views
That is interesting. Please keep posted as I am border line high cholesterol and they have debated wether they should risk cholestorol meds because I have a fatty liver, and it is a med that works throught the liver.
Nissa  |  January 10, 2014
Comment on this post
By stank mouth
October 15, 2013
stank mouth wrote
stanky mouth from metformin
Comment on this post
By donna dube
August 21, 2013
donna dube wrote
metformin and stomach problems
1363views
i take metformin also.i have these weird like hunger pains to the point where im in severe pain i have looked up everything my thyroid and other stuff i just dont know what to do i hurt so bad
Nancy Mosley  |  September 22, 2014
I had the exact same problem - my consultant advised me to take 1500 metformin at bedtime which worked brilliant I don't suffer in the day anymore!! Best advise find a brilliant endocrine professor!! After five wrong diagnosis from different doctors I found a brilliant endocrine specialist he is a researcher and he has patients from all over uk! I have other endocrine problems thyroid etc and if it wasn't for him I'd have been palmed off with painkillers by other doctors that were clearly not
Andrea  |  September 1, 2014
Correction..... Taken
Carolyn  |  April 10, 2014
I know the feeling. It gave me lactic acidosis. I am trying to be compensated by the doctors who prescribed it without considering that I had chf and kidney damage. I was t Ken off the drug but two weeks later I am still dealing the gas, bloating. A gastroenterology is who studies the digestive tract

Carolyn  |  April 10, 2014
Comment on this post

What patients are saying about Glipizide vs. Metformin

2,899 patient discussions from healthcare websites and blogs
but glipizide works well for me with absolutely no...
I've been on glipizide, another one of the 2nd ...it's different from glyberide, but glipizide works well for me with absolutely no side effects (I couldn't tolerate Metformin, and it didn't help m...
occ'l low blood sugar with night sweats, weakness, dizziness...
...daily of Glipizide. It works well, but when blood sugars began to climb for no apparent reason, I was changed to 10mg. Now I have occ'l low blood sugar with night sweats, weakness, dizziness OR m...
I think I would opt for the natural with NO side effects...
...1 cap twice a day, my day normally starts in low to mid 100's then about 10, 10:30 my BG drops less than 90-80. Then about 3-4 pm I have to fight to stay awake. Has anyone had any experiences with ...
better for me, with fewer side affects. It has also kept...
...after taking Metformin for years. The Glipizide seems to work better for me, with fewer side affects. It has also kept my...
metformin ER nor glipizide and am now doing well on...
...and I was in the 200's. I could not tolerate metformin ER nor glipizide and am now doing well on...
with Metformin. She cahnge me to Glipizide 2.5 mg twice...
...my blood sugars being so good.  Since I was having problems with Metformin. She cahnge me to Glipizide 2.5 mg twice a day. If my blood sugars...
I replace Metformin with Glipizide due to damage to...
...replaced my Metformin - ...The VA Doc recommended I replace Metformin with Glipizide due to damage to kidneys revealed in bloodwork.  However - whenever I take the 5 mg Glipizide - even if I...
I am now on metformin and glipizide and have no problems
...actos. I felt like my legs were cement blocks. I am now on metformin and...
you evaluate the change from Glipizide to Metformin Ext?...
...question. I was taking 15mg glipizide daily and have ...Ext Rel I didn't like the idea of glipizide so wanted to ...My question is, how would you evaluate the change from Glipizide to Metfo...
with a 10m glipizide at bedtime. This works for me most of...
...with a 10m glipizide at bedtime. This works for me most ...I was taking the metformin twice a day , but when I am working this dosage is too much and I have low blood sugar ( sometimes down to...
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