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Effexor vs. Tramadol for Pain

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/ 206,965 posts
Other Names: Effexor XR   Venlafaxine


/ 176,023 posts
Other Names: Ultram   Ultram ER   Zydol   Ryzolt
Rating: 3.5 out of 5
Based on 206,965 patient discussions on healthcare websites and blogs
Learn more
Rating: 3 out of 5
Based on 176,023 patient discussions on healthcare websites and blogs
Learn more
Venlafaxine (brand name: Effexor or Efexor) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive ... Read more on Wikipedia
Tramadol hydrochloride (Ultram, Tramal) is a centrally acting opioid analgesic, used in treating moderate to severe pain. The drug has a wide range of applications, including treatment for restless legs syndrome and fibromyalgia. It was devel... Read more on Wikipedia
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By C
December 11, 2014
C wrote
I take them for my ADHD /Dyslexia and they make me focus and feel well.
John  |  February 19, 2015
Tramadol makes me very hyper - not sedated at all. I had a decreased appetite, lots of energy and felt great. So I suppose that could be addicting, however, I took it for 3 months, and had no withdrawal symptoms at all. No side effects except weight loss, and my mother told me I was more pleasant to be around. Which, of course, made me wonder if I was normally unpleasant.
O  |  December 13, 2014
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By Rikko
October 7, 2014
Rikko wrote
Tramadol Addiction
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September 25, 2014
side effects
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By Angela
September 12, 2014
Angela wrote
tramadol and nightmares
The rest of my comment seemed to have been cut off, so I'll just finish it up by saying that some of the side-effects of true narcotics - like nightmares and itching or "crawling" skin - happen with tram too at higher doses, but they'll drop away again whenever you lower the dose, or even on their own at sustained higher doses (so long as the higher doses are taken as ordered and not messed with or abused. Moving between 50mg and 100mg as you are doing is fine.
con't  |  September 19, 2014
Nightmares are a common side-effect of opiate use, from the beast that is Morphine all the way down to little tramadol which contains only a small amount of synthetic opioid and has very weak effects on the u-opioid receptor - amounting to about 15% of the pain relief provided. The remaining 85% of tramadol's makeup is basically an SNRI anti-depressant, like Effexor or Milnacipran. In other words, as far as narcotics go, Tramadol barely qualifies as one, if at all. BUT it still has a few of the
Hugh  |  September 19, 2014
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By Doug
August 29, 2014
Doug wrote
My MD switched me from Diluaded to tramadol, i like the drug but blue cross does not cover it because diluaded is cheaper
John  |  October 3, 2014
Comment on this post
By nox
April 21, 2014
nox wrote
tramadol experience
Are you fucking retarded? I have taken tramadol off and on for a few years now and have had no problems with them. And have completely stopped them a few times with no withdrawal symptoms at all. But I only take up to 4 a day not 40..duh. use ur brain.
February 13, 2015
Anyone who. Compares tramadol to heroin does so from ignorance of the facts. I have used heroin in the past. I take tramadol 1-2 a week if pain gets unbearable. Try that with ANY opiates' and you will be using again the minute one hits your blood..
January 19, 2015
Do people really feel like it as pain releaver cause you sure hurts psycaly ina surden way and TRAMAOOL can maybe help and sure help my emotional pain aswell as few other minor pain Rlevant. Thanks. From Mr.H.O.Trygggvason
BLITZer  |  August 31, 2014
I have a script for Tramadol and take it at bedtime to sleep. I have severe leg pain that keeps me awake.. I don't notice any cravings to take more than that... 1 50mg Tramadol and 2 Diphenhydramine tabs and I'm down for the night.. I feel good the next day, unlike with Ambien and the others I've used.
Mark  |  August 26, 2014
sarsh  |  August 20, 2014
August 20, 2014
Great drug but makes me go to the toilet a lot
August 18, 2014
will I test positive on a oxycodone strip drug test by taking tramadol?
jay  |  August 15, 2014
That's one of the ways it just absolutly ruins your life! You will take all the ones you get prescibed(me 180 a month)after that you will spend your last dime to get them! No money, well in my case ruin your life even more by stealing anything and everything from your family... It's just an absolute shame and seems as if no matter how hard ya try your just taking 10 sis back!
gaboy  |  July 26, 2014
everything you have said is SO TRUE! I'm still struggling extremely bad with my addiction! I first got prescribed them when i was 14 dye to sports injuries/1-2 50mgtab every 4-6 hours. At first it was great, i was finally able to do even simple little things with out crying from pain. But when i was 16 me and my buddy decided to experiment and took 4each and noticed they made us feel loopy. So then is would occasionally take a few more than prescribed. By age 19 i was taking 10-12 at a
gaboy  |  July 26, 2014
They don't even do anything for My pain ..Just make light headed and have double vision when objects are too close it's a bitch to dial a phone
Matthew  |  June 28, 2014
Where were you able to obtain that many a day with a prescription? Thanks
Tonya  |  May 17, 2014
Try to get off of them before you get as bad as me. I've been taking 40-50 tramadol 50mg per day for ten years. I has completely destroyed my life and getting off of them is next to impossible, and I have no idea what to do. Trust me, if you're an addict, get off of them. They are highly addictive and the amount you take every day will get larger and larger. The withdrawal is severe. It's been compared to the withdrawal you get from heroin. Stop, or taper off ASAP.
Calyn72  |  April 22, 2014
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By theresa hawkins
March 26, 2014
theresa hawkins wrote
robaxin and seroquel
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By Can't wait to get back to Tramadol
February 19, 2014
Can't wait to get back to Tramadol wrote
Dilaudid vs. Tramadol
Congratulations, you apparently are not addicted to opiates nor enjoy them too much. Dilaudid would keep me stoned, with a euphoric feeling.
JesseJames  |  October 8, 2014
Comment on this post
By Tramadol rash
February 8, 2014
Tramadol rash wrote
tramadol rash
I am currently battling what looks and feels like psoriasis on my eyes, spreading quite quickly. Extremely itchy. Have been told that it's 'definitely eczema' and 'just dermatitis' by doctors and have been prescribed numerous creams, none of which are helping at all really.

The only thing I can think is that I'm either having a reaction to some certain shower gels, or it's the tramadol which I have been taking for horrendously bad back pain, (the amount of time taking tramadol and itchiness ar
ThisGuy  |  January 29, 2015
I had a horrible rash and my face looked like I had been burned.I would never use it again.
Dilaudid was the best pain pill ever and was not addictive.
Joanne  |  August 29, 2014
I did not have a rash but itched all over. I thought I had hives and checked my body but there was no rash evident.
Joanne C  |  August 29, 2014
Oh yeah!! Went to the hospital at 4:00 in the morning with rash on my arms so bad they almost blistered and it felt like someone was ripping my arms off.
Brenda  |  July 23, 2014
Yes rash hives itching
May 26, 2014
Sounds like your allergic to opioid pain medicine.
March 10, 2014
Comment on this post
By Kaleigh 25 Yr. Old Female in Baltimore, MD
February 5, 2014
Kaleigh 25 Yr. Old Female in Baltimore, MD wrote
Taking Tramadol & Phentermine Together
The MD knew withdrawals are going to be expected. I was given chlonodine and phentermine to help. It worked will and now I am off meds. All this tx was supported by studies. A general MD will not have the knowledge to feel comfortable.
Rudy  |  May 31, 2014
Try to find a MD who is a pain management specialist along with being an addiction specialist or addictionologist. These doctors are much more knowledgeable on pain management along with other treatment that will help support your pain management. For example, my pain management MD had me on a pain med from a chronic injury. He also discovered I needed testosterone. After a year of treatment my chronic pain was feeling so much better that we decided to try to stop the pain meds. The MD kne
Rudy  |  May 31, 2014
It works like a miracle pill for me...almost at my weight lose goal...
cynthia  |  May 20, 2014
It made me hungrier too..dr took me off it cause I would gain and lose..looking in to something diff.
I' m bernita  |  April 30, 2014
does the phentermine work for you? seems to make me hungrier
jennifer  |  April 8, 2014
So how did your doctors appt go?
Chavez  |  March 12, 2014
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By dee
January 16, 2014
dee wrote
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By Jcaudle
January 15, 2014
Jcaudle wrote
Shakey hands
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By schorel
December 7, 2013
schorel wrote
Allergic reaction to tramadol
Comment on this post
By Fabs
December 1, 2013
Fabs wrote
Cipralex vs Effexor
I was first treated with Cipralex, for Depression NOS, but it made me numb/depressed after 3 weeks. I eventually self-diagnosed with cylothymic disorder and my new pdoc has me on Effexor. It has almost instantly knocked out my ptsd. There are usually a couple days of exhaustion and restlessness when raising dosage. Despairing thoughts no longer frequent the mind. Course of treatment -1 year.
Spudz  |  July 5, 2014
Comment on this post
By Shadowboxers
November 22, 2013
Shadowboxers wrote
Bursitis pain
Could be a cartilage tear, mri arthrogram
Chris  |  January 6, 2015
Shadowboxers comment makes little sense, Endone IS Oxycodone, its just a brand name, so finding one more effective is meaningless!?
bono  |  January 2, 2015
If its been a long time its not bursitus its sciatic nerve problems..go to orthopedic and get an mri ive had this for eight years same thing and after the drs kept repeatedly telling me it was bursitus and to basically suck it up i started goin to different drs who pointed me in the right direction
regina  |  July 15, 2014
Comment on this post
By Katelyn 17
November 21, 2013
Katelyn 17 wrote
taking keppra and tramadol at the same time..
Say what ? How do you think I got tramadol. DR wrote me a script. Now maybe he had no real exp with epilepsy. I was 6 yrs free of siezures until I was off my meds for awhile. Sure enough epilepsy is going to be around 4 ever. So taking tramadol is better than taking narcotics for pain relief. I will take my chances with medical supervision. Threshold this and that. Even before I took my siezures serious , I was lucky 1 @ year to1 1/2 off siezure free. Mine are clearly stress related also h
martin  |  February 2, 2015
I tramadol all the time with 500mg of keppra. Mood swings oh boy. Agitated oh my lord everyday with anxiety. Mother nature is on my side. I smoke herb for medical reasons now.
martin  |  December 28, 2014
Keppra is a seizure med. It made my wife go through what you described. Her doc changed her to lamotragene (spelling is off on that). My concern is that tramadol is not supposed to be taken by people with epilepsy. Or anyone with a higher chance of seizures. It lowers the threshold for seizures. So if you have seizures and are still taking tramadol, please talk to your doctor asap..m its not safe.
caution  |  June 10, 2014
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By dave
October 17, 2013
dave wrote
Mobic vs Tramadol
Mobic is in the same class as ibuprophen, Aleve, etc. They are all NSAID (non steroid anti inflammatory drugs) and Tramadol is not a narcotic pain med but it does mimic some opiate pain meds and gives you pain relief similar to taking an opiate
FFMom  |  April 16, 2014
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By Maujy
October 9, 2013
Maujy wrote
Its now ages since I posted my lot about stopping tramadol and just happened to come across my post and the reply. Wish that one would be notified of a post but anyhow. You are sooooo right about the doctors needing to go back to school. Here in south africa one gets some doctors that only work at the state hospitals......they are well paid but become slap dash because the have about 30 patients per day to get through. So one is no sooner in the doctors room then out...they are very sweet but o
maujy  |  July 17, 2014
im so sorry you had such a shity Dr. she needs to go back to school tramadol is hard ,hard, hard, to stop!!!!!!!!!!!!! I know the answer to your prob go to a pain Dr. they will help you not these 22 year want a be Doctors they cant wipe there own,you know!!!!!!!!!!!!!
greg  |  February 8, 2014
Comment on this post
By dirk cunnington
September 10, 2013
dirk cunnington wrote
In praise of Effexor - wonder of wonders
This drug is horrible. It gave me a headache everyday for 6 weeks. I went off of it, and was extremely ill. I couldn't even get out of bed one of the days....sharp head pains, vomiting, diarrhea, nausea. DO NOT take this medication until you learn the withdrawal symptoms. Easing off of it slowly just prolongs the agony.
Sue  |  October 15, 2014
I concur wholeheartedly! "SO, don’t criticize Effexor because it didn’t give you what you were looking to get – embrace it because it takes you to a better place that you never knew existed. But you have to want to go there, to find your true self." Well said. By-the-by; I was recently rx'd a serotonin making drug called amyltriptaline- poof; brain favors it truly. Utopia might be some Mu receptors and Celebrex; then no unnecessary toil on my brain nor being nor spirit. Ah, but such is lif
dutchfish  |  June 13, 2014
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By Elizabeth
September 6, 2013
Elizabeth wrote
Effexor & Swollen Feet
How long did it take the swelling to go away? I'm experiencing this now after 2 weeks off of effexor 75mg. I decided I wanted my life back and stopped taking it. It's starting to hurt and I can barely stand for long periods of time. Please do respond and let me know if this gets better. I greatly appreciate it. email me at xxxx@xx.com if you could.
Rodney  |  January 19, 2015
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By judy
September 1, 2013
judy wrote
i have lost my mind completely
you are likely to have bpd ,,, Prozac. tegratol, and Haldol as needed worked miracles for my husband. First Prozac for 2 weeks and then add the tegretol don't know why the wait but it worked miracle like this,
monica  |  January 7, 2015
I was diagnosed with BPD and PTSD 22 years ago after a TBI. I've been on Effexor and Aderal since. I can't live without Effexor, it stabilizes my disregulated emotions but does nothing to stop the flashbacks. The only thing that I've found that will do that is Opium, which I don't want to go there, or some strains of canibis, which I do. I'm sill trying to find a pharma solution. My new research stream is that maybe adding Aricept might help. Anybody have any experience with that?
Chris  |  December 9, 2014
Does takeing covesyl lesson the effect of efexor
diane  |  August 26, 2014
wish you did too
August 20, 2014
I was on high dose effexor and also "lost" several years. I simply STOPPED taking this drug, and with the help/love/understanding of my wonderful lady, I have (so far) been able to function without it. For the first time in a long while, I am aware of what I am doing. It has been five LONG months, but..... I CAN DO IT!!
Russ  |  August 20, 2014
I can totally empathise with you I feel exactly the same - I am suffering from Anxiety & Depression have been taking venlafaxine and flupentixol for years and although I am much worse without the meds I still manage to embarrass myself on a regular basis to the point my eldest son is ashamed of me and doesn't care about me anymore. I worry constantly that the rest of my family will soon decide I am not good enough for them also and they will start to look down at me and decide to disown me, too
Diane  |  July 26, 2014
I understand what you are saying and how you feel. I think my son cares as well as a few other people but they are just tired of hearing it. I know I am and I'll bet you are too. I don't have any magic words. I wish I did.
Bonnie  |  March 27, 2014
Comment on this post
By Pain Patient
Pain Patient wrote
Tramal = hallucination, anaphylaxis and loss of conciousness
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By Ryan
Ryan wrote
Endone and Tramadol
Comment on this post

What patients are saying about Effexor vs. Tramadol

1,389 patient discussions from healthcare websites and blogs
I quit takin Tramadol daily & was takin my Effexor, I...
...be careful! Before I quit takin Tramadol daily & was takin my Effexor, I had a seizure the 3rd night. ...more than 300 mgs Tramadol all day. ...
anyone here tried long acting tramadol as double-duty ad...
...that effexor was derived from tramadol. Can ...this? Has anyone here tried long acting tramadol as double-duty ad and pain-reliever? (Was on effexor years back--was more effective IMO than...
just I needed pain relief and mixing tramadol with Effexor...
...ago in April I take tramadol 50mg 2 to 3 times ...along with 150mg xr of Effexor I think this combo does ...a good thing just I needed pain relief and mixing tramadol with Effexor seems to wo
50 mg of Tramadol 3X a day really help me. I used to take...
...and 50 mg of Tramadol 3X a day really help me. I used to ...not work as well as Tramadol. I take Effexor ER 150 mg a day and it is great for my depression. This is what helps me. Stevie and D...
Tramadol has been helpful for me. Granted, it contains...
...Effexor. Have you tried it? I'm not ...resurgence of effexor as a double acting agent for pain and depression. Maybe will not work as well for pain. Tramadol has been helpful for me. Grante...
a day isn't enough to do anything including relieve pain....
...Tramadol a day isn't enough to do anything including relieve pain. You will be ...then10 yrs with effexor and nev...
but I guess it works for some. Tramadol helps me but...
...tried Elavil and recently Effexor, both antidepressants, and just one dose caused bad side effects. Not a fan of ...of treatment but I guess it works for some. Tramadol helps me...
other then nausea(sp) from the tramadol. As for the...
...take 75 mg of effexor in the morning ...night and then take tramadol as needed for pain during the day or night. I haven't had any problems other then nausea(sp) from the tramadol. As for the s...
1 year tramadol didn't do anything anymore. I had to switch...
After about 1 year tramadol didn't do anything anymore. I had to switch ...migraines. But to get my every day average pain down the effexor has done a pretty good job. Also, try asking...
I LUV TRAMADOL. That stuff is AWESOME, k/o'd my OCD inside...
...relief from OCD. I have tinnitus - and the extra ringing from the Effexor is bothersome and a ...AND - I was on Tramadol after a surgery ...and I LUV TRAMADOL. That stuff is AWESOME, k/o'...