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Other names: Celecoxib
Method of use: Pill
Prescribing mode: Rx
Celecoxib International Nonproprietary Name is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor use...
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Celebrex for Pain
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Does Celebrex cause Itching All Over ?

#269 in Celebrex discussions - 9 posts discuss Itching All Over with Celebrex. Itching All Over is #269 concern in Celebrex discussions.
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Itching all over...Celebrex, Methotrexate, Hydrochlorothiazide the cause???
I have been taking 200 mg of Celebrex for OA for over 4 years with good results, 12.5 mg of HCTZ for over two years, and about two months ago began taking 5 tabs 2.5 mg of Methotrexate for RA. All was fine until a week ago when I started itching all over, head to ankles. The ONLY places I do not itch are my hands and feet. I feel like I am being tortured!! Benedryl did nothing to help so I am now taking RX antihistamie Amlodipine Besylate 5 mg four times a day and prednisone daily, plus my RA doctor immediately took me off the MTX and switched out the Celebrex and HCTZ for other meds (I am also going through bottles of Gold Bond Medicated lotion like crazy!). He is not sure which is the culprit so is trying this route before reintroducing the Celebrex and HCTZ. Has anyone else had the issue of whole body itching with any of these meds? I know any one of these drugs may have itching as an issue but with the timing I am leaning toward the methotrexate. Or is there something that can trigger an allergic reaction like what I am having? I know I have to be careful about being in the sun; my family went to the beach about a month ago but I would think a reaction would have been sooner if sun was the cause. Any ideas? Help!!
May 10, 2015
amlodipine is not an antihistamine
March 5, 2015
It is probably from your pain meds. Narcotics have the same effect on me.
December 31, 2014
I am also on methotrexate injection and itch all over. I also take folic acid and several other medications but the itching didn't start until I started opioid pain killers. I don't think its one or the other I think it is the combination of all three. My doctor has told me to take antihistamines when it is no longer tolerable.
December 2, 2014
CELEBREX does contain sulfa. If you are allergic to sulfa, that could be cause of rash

Susanne Deumig
April 21, 2014
The problem could actually be Fibromyalgia, which many people with RA suffer from.
February 1, 2014
Txbetty and Hal, Like both of you, I have been on Celebrex for at least a year. I also take HCTZ 12.5 mg and started Methotrexate two months ago. I did have itching all over like you described, Txbetty, and I figured out that it was simply the particular brand of folic acid I was taking. It's been a long time since you wrote your post, but I happened to see it and wanted to comment. I assume you are taking folic acid if you are still on MTX; if you are still itching then it is something to
August 25, 2013
I have been on Celebrex for over a year and had fantastic results. I suffered pain in my neck and shoulders due to arthritis. Celebrex was like a miracle for me. I was going to physio for the pain, which did not good. Now after being pain free for one year I have been experiencing extreme itchiness all over my body. It feels like something crawling in my scalp, eyebrows, nose and beard. Then it feels like something biting me and there is nothing there and I have no bites . Yikes.

Post from
have had bad itching all over and slight burning sensation...
" ...Sulfasalazine or Celebrex ** Originally posted by geordieboy44 ** Hi everybody In the last few days have had bad itching all over and slight burning sensation as well. ...on taking the Cel... "

I am also allergic to celebrex, Maybe if you can...
" ...no dr knew what was going on, by trial and error I quit taking fish oil capsules and I ...feeling of getting warm and itching all over. If not that ...am also allergic to celebrex, Ma... "

the market. He is allergic to Celebrex, so this was going...
" ...got intense itching all over ...hasn't had a problem with itcing since. So he is really bummed that he can't use it. He was taking Vioxx but they pulled that off the market. He is allergic to... "

Please help. I am itching all over. Have been for 6 months...
" ...generalized itching. Tried Lyclear. History of RLS Please help. I am itching all over. Have been for 6 ...keeps recurring. I have RLS and have just stopped taking celebrex . And stopped taking... "

Post from
go back to Celebrex. That helped alittle. This does seem...
" ...been taking this medicine for 5 days. Yesterday I started to feel itch ...have itching all over the ...and go back to Celebrex. That helped alittle. This does seem to help more than Celebre... "

Post from
reaction to celebrex (celecoxib) which involved itching all...
" ...as well? I only ask because I recently had a drug reaction to celebrex (celecoxib) which involved itching all over and a rash that sounds similar to yours. No bruising, though. It definitely... "

15 or 20 yrs. mostly Celebrex. Have sjogrens my doc thinks....
" ...20 yrs. mostly Celebrex. Have sjogrens my doc thinks. Dry mouth!!!! And generalized itching with no rashes. ...I also take zanaflex 2-4 mg klonopin 1 mg 2 Neurontin Still have prob with insomnia... "

Post from
What kind of itching? All over, rashes,? I'm an \" itcher...
" ...prednisone for. What kind of itching? All over, rashes,? I'm an \" itcher ...adjusts to being without the Celebrex soon, and I hope ...and not a flare. Since Celebrex is an antiinflammato... "

Post from
from going off the Celebrex. Time will tell, I guess....
" ...just from going off the Celebrex. Time will tell, I guess. ...prednisone for. What kind of itching? All over, rashes,? I'm an \" ...body adjusts to being without the Celebrex soon, and... "

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The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you.
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