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Accutane vs. Doxycycline for Acne

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/ 346,627 posts
Other Names: Isotretinoin   Claravis   Amnesteem   Sotret   Isotrex


/ 48,891 posts
Rating: 3 out of 5
Based on 346,627 patient discussions on healthcare websites and blogs
Learn more
Rating: 2.5 out of 5
Based on 48,891 patient discussions on healthcare websites and blogs
Learn more
Isotretinoin, International Nonproprietary Name, is a medication used mostly for cystic acne, however, it is also employed for a number of cancers and a few severe skin conditions. It was first developed to be used as a chemotherapy medication for the t... Read more on Wikipedia
Doxycycline International Nonproprietary Name is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. Doxycycline is a semisynthetic tetracycline invented and clinically developed in the early 1960s by P... Read more on Wikipedia
Concern level
Top 3 Concerns
Dry Lips
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Concern level
Top 3 Concerns
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See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with Accutane or Doxycycline - your story could impact others.
Treato My Voice
By denny
December 10, 2014
denny wrote
accutane and hyperostosis
Comment on this post
By R_Beauty
September 28, 2014
R_Beauty wrote
Raccutane caused me huge chest pains and difficulty breathing
Comment on this post
By Junetantin
September 21, 2014
Junetantin wrote
Doxycycline hyclate and monohydrate
I take it with water. Can i have any calcium during the day?
Eve  |  November 8, 2014
im in month 1 and i had a bad side effect taking the doxycycline 100mg which leads to tiredness and sore back i cant even sit prob at all. Eventhough my face statred to become smooth and no more acne but does anyone know if i need to reduce the mg or keep taking until the acne gone.
October 6, 2014
Comment on this post
By Emin
August 6, 2014
Emin wrote
Accutane ( Isotrenion)
you must inform your doctor about what is happening to you . I couldn't even complete 1 week of raccutane if was giving me horrible side effects
September 28, 2014
Im on month 2 n also have blood taste in my
Mouth and nose bleeds often. Keep ur nasal cavity dry by puting lotion in ur nostrils and drink lots of water
September 17, 2014
Comment on this post
By Brooke
July 24, 2014
Brooke wrote
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By Jeff
July 4, 2014
Jeff wrote
I know for a fact doxycycline drove my dad crazy and he took his life .
nicole dailey  |  October 1, 2014
My extreme 10 yr urinary incontinence stopped after 2 days on 100mg doxycycline treatment for tick bite. Limited urination & right hip pain. Apparent bacterial redness,swelling in arm cleared up quickly. Am afraid Kidney's have shut down. 66yrs old.
MH  |  July 21, 2014
Actually you can take doxy with food, there is no evidence that food interacts with doxycycline. You're stomach just needs a high level of HCL acid for doxy to work. Just don't take it with anything that contains high levels of Calcium in it. No DAIRY!
July 5, 2014
Comment on this post
June 6, 2014
GG wrote
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By sav
May 16, 2014
sav wrote
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By NightDiver
March 11, 2014
NightDiver wrote
May I ask how old you are? I'm a 50 year old female, and my acne sounds like the exact same kind as yours. Considering Accutane again, since I'm just fed up and can't tolerate Spiro. First course, when I was 25, put me in remission for over 15 years. Thanks!
Rena  |  June 1, 2014
Comment on this post
By Aimee
March 8, 2014
Aimee wrote
Natural alternatives to Accutane and other chemical cures
Where can I purchase that bentonite clay?
Lea  |  October 18, 2014
Happy that this method worked for you! But there's no one cure-all for anyone. I tried every possible solution over a number of years and nothing worked. I was reluctant to try Accutane for the reasons you've mentioned, but it's worked for me (with side effects)
NightDiver  |  March 11, 2014
Comment on this post
By Allison
February 27, 2014
Allison wrote
Doxcycline and Levaquine - Tendonitis
Comment on this post
By Bibby
February 22, 2014
Bibby wrote
Accutane chronic stiffness years later
November 18, 2014
Never thought about it but my chronic back pain started the same time I was on accurate, and it is still ongoing pain. What if the agent used to dry the oils causing the acne also dried spinal fluids and other essential oils needed by the human body to live healthily. I hate pills and always have but accutane is by far the worst I've ever taken and have heard the same from anyone I know who has taken it to. It's criminal what pharmasutical companies get away with I'm their search for wealth and
Lucas kane  |  October 15, 2014
I forgot about this post, but thanks for the response. I've been screened for Lyme, but the test came back negative. I live in southern British Columbia (Canada)-- not sure how prevalent Lyme is here, but I know it's nowhere close to as high as it is further East. I know the tests can be inaccurate, so I guess there's a possibility that Lyme might be the cause. Any ideas on accurate tests to diagnose it?
Bibby  |  July 6, 2014
Consider Lyme disease. A lot of the side effects of Accutane are the symptoms of Lyme. Therefore it makes it tough to know for sure. However, since Accutane weakens your defenses the bacteria advance. Your broken ankle was a traumatic event that probably didn't help anything. It may seem lame, but Lyme disease is a hidden epidemic in this country. It crosses the placenta, and some sources think it can be transmitted sexually. Most of the time testing reveals little clues, even the testin
Jaz  |  March 5, 2014
Comment on this post
By Horrified
February 19, 2014
Horrified wrote
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By Masood Akbarzada
February 11, 2014
Masood Akbarzada wrote
ACCUTANE - Watery Eyez, runny nose, body stifness, stress, Anxiety, Lack of work will,
I'm very interested in your specifics. I am 55 female with Roscesa (bumps on face but no redness). I've been taking Accutane for 3 weeks and have a few side effects. Typical dry lips and some overall dryness but am just starting to experience brain fog. Did you have brain fog and if so did it go away once done with treatment?
Hopeful User  |  August 9, 2014
Comment on this post
By Andrew
February 3, 2014
Andrew wrote
Accutane - Forgetfulness
You need to go in I had foggy brain and I also got type 2 diabetes from accutane at 23 and I am only 120 pounds
April 19, 2014
This happened to my son in college. The accutane caused damage to his brain to the point he fainted during a test, had to go to the hospital and doctors were convinced he had multiple sclerosis. Accutane destroyed the coating on the neurons. Please go and have the ms test. My son stopped accutane and is slowly improving. But has constant migraines and anxiety.
True  |  February 19, 2014
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By nurse with photophobia due to eye infection
January 26, 2014
nurse with photophobia due to eye infection wrote
Severe Painful Photophobia following eye surgery
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By Ay_yo_D
November 20, 2013
Ay_yo_D wrote
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By The Momma
November 4, 2013
The Momma wrote
Me too. Three days worth and I dreamt my cat got out and fell down a fifty foot hole in the driveway. That was the least of the dreams. Stopped the pills after three days but following night had the cat dream. Believe can take anything from a week to three months to get out of the system, depending on amount taken. My very best wishes to your daughter and well done for spotting something wrong.
Minky  |  June 3, 2014
Me 2 (oo)
Kylie  |  April 4, 2014
Comment on this post
By daniela
October 19, 2013
daniela wrote
Do I use Dalacin T. and BP at the same time?
Comment on this post
By Carriecarrot
September 28, 2013
Carriecarrot wrote
Shingles and accutane
I am on my third round of accutane at age 30. I took it when I was about 17 years old and also developed a case of shingles. Never occurred to me that the two were linked.
Mike  |  August 27, 2014
Comment on this post
By KaylaKitty
September 6, 2013
KaylaKitty wrote
Accutane and an Appendectomy
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By cmsf
September 5, 2013
cmsf wrote
Comment on this post
By Mary
August 26, 2013
Mary wrote
Doxycycine is poison!!
You CANNOT take doxy without first filling the stomach with food, or you might as well force yourself to puke because it is really nasty to go through the whole process to get there if you didn't first eat before doxy, so cut to the chase and get it over with. Doxycycline should not be taken for a few days and then stopped unless you want to become resistant to powerful antibiotics and get really sick one day. Follow the directions to eat first and you'll be fine.
jess  |  February 1, 2015
I have been really nauseated for the first week, and now I am much, much better. I am on for Lyme disease, and I will tolerate most anything to get this horrible disease out my body. Now the only problem I am having is mouth sores on the right side. I can deal. Lyme has been very difficult to take and I have had more things wrong with me. I can take nausea and mouth sores.
IK  |  December 22, 2014
Doxycycline .. stay out of sun, it can cause Sun burn
December 11, 2014
Bob  |  October 28, 2014
My neck is real read itchy and peeling then burns
Tammy henry  |  April 17, 2014
I have been taking these twice a day for almost the last month for my perioral dermititis. I did try taking them without food which is the best way for them to be more effective. However; I did notice that especially in the morning it makes me quite nauseous. You MUST drink alot of water and even if you do you may have to eat a little with them. It is a pretty powerful antibiotic and honestly one of the main issues can be dehydration which can cause all of the symptoms listed in previous post.
Larisa  |  March 24, 2014
Were you guys eating with your antibiotics? They can make you very sick on an empty stomach.
February 28, 2014
just lower your dosage i guess and eat yogurt+ drink alot of water
powmowpow  |  January 16, 2014
I was put on Doxy 1 100 mg 2 times a day. I started a heacache and nauseous feeling. Kept taking them until the 5th day. My headache was so severe, nausea was worse. I couldn't take the headache anymore. Looked up side effects of doxy and first one was a severe and unusual headache, then nausea....etc. I stopped them, drank lots of water to flush it out of me. Headache gone within a couple of days. Spoke to my dr and got a script for something different.
Whew, worst headache ever!
ChristineW  |  November 15, 2013
Comment on this post
By Speshlk
August 16, 2013
Speshlk wrote
Accutane helping gluten intolerance side effects
What's up man.

Looks like this is an old post, so with any luck, you've already done what I'm about to tell you to do. GO GLUTEN FREE! DO IT! I had the same symptoms, minus the dizzy/tilting sensations but plus inattentive ADHD and dermatitis. For about 3 months, I cut back on gluten, but I soon realized that's not good enough. See, when you reduce the amount of gluten you consume, your tolerance to it also decreases. That means if you don't eat it for a couple weeks, and then give yourself a
J  |  April 29, 2014
Comment on this post
By Tayla
Tayla wrote
Head pressure from doxycycline
Comment on this post

What patients are saying about Accutane vs. Doxycycline

3,004 patient discussions from healthcare websites and blogs
I switched to accutane for about a year and it worked...
...form of doxycycline and it helped, but I didnt like the side effects. I got severe dry mouth, and had some problems with sweating. I switched to accutane for about a year and it worked very well,...
. I hear accutane is better but i never tried . And i heard...
...months after cycle before i went to the docs . He perscribed me doxycycline , wich took a month but worked great . I hear accutane is better but i never tried . And i heard...
did have side effects severe dry eyes and very chapped lips...
...to wash my face. So the derm recommended I take doxycycline for one month to clear up my face that even worked. The accutane did have side effects severe dry eyes and very chapped lips. It also...
worried about the sides, my side affects were minor dry lips...
...it came back. ACCUTANE! Stop being so worried about the sides, my side affects were minor...
doing that good so he switched me to Accutane. He wants me...
...I was previously on doxycycline and it worked. However I ...that good so he switched me to Accutane. He ...have now. So I should let my current symptoms subside and then start the Accutane...
is the most effective acne medication but it is often...
Accutane is the most effective acne medication but it ...serious side effects..Also,doxycycline worked great for me a year...
and the accutane did nothing long term. Good luck. I...
...clear and the accutane did nothing long term. Good luck. I used doxycycline for years with great...
I just want the dam accutane! where did u go through?...
...me on two medications, Doxycycline? and Monocycline? And they didnt work. I dont wana go ...just want the dam accutane! where d...
as expensive as Accutane and works great if your acne isn't...
...works well, it's a pill... Not NEARLY as expensive as Accutane and works great if your acne isn't severe. Not really any ...it, except that m...
than the side effects from accutane (basically just dry...
accutane isn't a new drug. it's ...majority of people using accutane have no problems ...the side effects i got from doxycycline were much more severe than the side effects from accutane (basic...