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5-HTP vs. St. John's Wort for Bipolar Disorder

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5-HTP

OTC
/ 80,374 posts

St. John's Wort

OTC
/ 31,054 posts
Rating: 3.5 out of 5
Based on 80,374 patient discussions on healthcare websites and blogs
Learn more
Rating: 3.5 out of 5
Based on 31,054 patient discussions on healthcare websites and blogs
Learn more
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (International Nonproprietary Name), is a natural product amino acid and chemical compound precursor (chemistry) as well as metabolic intermediate in the biosynthesis of the neurotransmitt... Read more on Wikipedia
St John's wort (traditionally now commonly , as spelt) is the plant species Hypericum perforatum, and is also known as Tipton's Weed, Chase-devil, or Klamath weed.With qualifiers, St John's wort is used to refer to any spec... Read more on Wikipedia
Concern level
Top 3 Concerns
Serotonin Syndrome
Did you have
this too?
Nausea
Drowsy
Concern level
Top 3 Concerns
Serotonin Syndrome
Did you have
this too?
Nausea
Dizzy
See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with 5-HTP or St. John's Wort - your story could impact others.
Treato My Voice
By Pattii
October 3, 2014
Pattii wrote
5 HTP
Comment on this post
By Isa
September 13, 2014
Isa wrote
5htp irregular heart beat and bad dreams
Comment on this post
By Dm3
August 30, 2014
Dm3 wrote
Intersting, but unstable.
Ginkgo biloba isn't an SSRI.
Jon  |  September 13, 2014
Comment on this post
By Joey
August 5, 2014
Joey wrote
5 HTP ( 30 days personal experience)
1919views
Comment on this post
By Joe
February 27, 2014
Joe wrote
5 HTP side effects
3205views
5-htp should not be taken with ssri... I take 300 mg per day, since 2008, no such effects. (while having lot of anxiety, i am not scared of 5-htp...)
Bernhard  |  October 8, 2014
I am taking Celexa an SSRI and wanted to taper off so I went from 20mg to now 10mg which sucks for my mood and headaches. I took one pill of the 5HTP to offset my deminished Celexa and waited 15 minutes and ate some ice cream ~ I immediately felt numb, cold sweats, clammy and vomited all of my ice cream, bummer, I'm scared to try another 5HTP pill :(
Jenn  |  August 17, 2014
Comment on this post
By Sharon
January 15, 2014
Sharon wrote
5HTP and muscle pain and joint pain
1997views
I took 50mg thought I was going to die. It made me so depressed.I hope the depression will go away soon.It has been 2 days now.If it don't go away I am going to the hospital.
margie  |  May 5, 2014
Comment on this post
By Logan Eros
January 7, 2014
Logan Eros wrote
No safe level of 5-htp. . .one last thought
3104views
Comment on this post
By Logan Eros
January 5, 2014
Logan Eros wrote
No safe level of 5htp contd.
2332views
There are many things wrong with this post.

Serotonin syndrome is not caused by an impurity in a supplement. Serotonin syndrome describes a rare state wherein the body makes too much serotonin or doesn't clear it properly, usually because two or more medications affecting serotonin levels have been mixed. This usually involves large doses of something like a cold medicine being taken on top of an antidepressant or recreational abuse of a substance that affects serotonin levels. (Robitussin, f
August 26, 2014
what brand were you using? did you ever look up literature to see if they conducted an assay on your particular brand? 5HTP is a naturally occuring chemical in your body and generally those who are depressed have a deficency. I think you are correct about it being synthetic but it sounds like they were selling something other than advertised. Lastly, eosinophils are a natural type of white blood cell in every human. they can be involved in serious blood disorders but those with eosinophils so
January 27, 2014
Comment on this post
By Logan Eros
January 3, 2014
Logan Eros wrote
No safe level of 5htp
1869views
Definite symptoms of serotonin syndrome, perhaps your body already had a balances serotonin level prior to taking 5htp
J.White  |  August 1, 2014
Comment on this post
By Dawn
November 22, 2013
Dawn wrote
Wellbutrin v. St. John's Wort
2603views
WTF is HTP?
WTF  |  September 4, 2014
What is 5HTP?
5HTP  |  September 4, 2014
Never taken it
July 8, 2014
what is htp?
star  |  April 14, 2014
Dawn thank you so much for sharing your experience, I have been affraid to try the st. johns wort and 5htp because they say you can get seretonin syndrome. I definitely want to give this a try. Have you found any research about this? Thanks in advance for your help
Devin  |  January 3, 2014
Comment on this post
By Kjartan
November 12, 2013
Kjartan wrote
5-HTP for sleep
1810views
Comment on this post
By CookieZ
September 2, 2013
CookieZ wrote
5 HTP
1405views
Comment on this post
By Eleanoro
August 27, 2013
Eleanoro wrote
5HTP made me mean
2047views
I've been taking 5-HTP for chronic anxiety disorder (CAD) and depression for about 3 years now
and have never experienced what all the above have. You start out slowing taking 5-HTP, as
indicated on the bottle, and I never exceeded 3 per day. I'm now down to only one per day,
stated on the bottle, and I never took it before bedtime. I don't have anxiety or depression while I'm sleeping, so why would I need to. My doctor paired it with Gaba Calm, so ask your health
care professional if he/
Kay  |  June 21, 2014
I heard that it could cause aggression and road rage type symptoms. I have not experienced this though, and I've been taking it for about 4 weeks. I've actually had more restful sleep since starting it and seem a little more relaxed.
5HTP for Depression  |  June 18, 2014
so that explains my aggressivity..also I had nightmares
Judy  |  February 18, 2014
Comment on this post

What patients are saying about 5-HTP + St. John's Wort + Bipolar Disorder

61 patient discussions from healthcare websites and blogs
or St. John's Wort. 5 HTP helped me but sent my Bipolar too...
...diagnosis. I am so sorry you lost your friends. My Mom takes Effexor for depression, she really likes it and it helps her.Some people find taking 5 HTP or L Tryptophan works, possibly even...
has worked for me and has clinical data to support it's...
5-HTP has worked for me and has clinical data ...the supplements section. St. John's Wort did nothing...
I take 5-HTP and it seems to regulate my moods and help...
...St.John's Wort also helped but made me a little queasy. I take 5-HTP and it seems to regulate my...
but everyone is different. 5 HTP is what has helped...
...it helped me depression, but everyone is different. 5 HTP is what has helped me with...
used to take the 5htp at bedtime and it really helped with...
...ahve any problems I used to take the 5htp at bedtime and it really helped with my sleep ...better than st john's wort ...
I have tried 5HTP No results. St John`s Wort no...
...good for say Anxiety-Depression-Mania? I have tried 5HTP No results. St John`s Wort no results. Fish oil? B12 energy at...
using before 5-htp came to the stores. It works great for...
...wild here. 5-htp Didn't do anything. Actually ...were using before 5-htp came to the stores. It works great for ...time. Also check out http://www.sjwinfo.org/ -- they have a great forum ...
minimizes the withdrawal symptoms: -5 HTP -St John's Wort...
...as you stop Effexor as it minimizes the withdrawal symptoms: -5 HTP -St John's Wort -Tyrosine However, which is the best and how...
a few weeks to work. 5-htp works great for depression as...
...so is st. John's wort. It doesn't work for everybody ...to work. 5-htp works great ...
I highly recommend the book (and the 5-HTP, though you...
...John's Wort, but I've taken 5-HTP with great success. Have you ...several options, including St. John's Wort. I highly recommend the book (and the 5-HTP, though you shou...
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