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5-HTP vs. Melatonin for Insomnia

5-HTP

OTC
/ 79,249 posts

Melatonin

OTC
/ 188,552 posts
Other Names: Melatonin (With B6)
Rating: 4 out of 5
Based on 79,249 patient discussions on healthcare websites and blogs
Learn more
Rating: 4.5 out of 5
Based on 188,552 patient discussions on healthcare websites and blogs
Learn more
5-Hydroxytryptophan (5-HTP), also known as oxitriptan (International Nonproprietary Name), is a natural product amino acid and chemical compound precursor (chemistry) as well as metabolic intermediate in the biosynthesis of the neurotransmitt... Read more on Wikipedia
Melatonin , also known chemically as N-acetyl-5-methoxytryptamine, is a naturally occurring compound found in animals, plants and microbes. In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the Entr... Read more on Wikipedia
Concern level
Top 3 Concerns
Serotonin Syndrome
Did you have
this too?
Nausea
Drowsy
Concern level
Top 3 Concerns
Anxiety
Did you have
this too?
Sleepy
Groggy
See all concerns, alternative treatments and more
See all concerns, alternative treatments and more
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Help people by sharing experiences you've had with 5-HTP or Melatonin - your story could impact others.
Treato My Voice
By Isa
September 13, 2014
Isa wrote
5htp irregular heart beat and bad dreams
Comment on this post
By blahblah_gc
September 7, 2014
blahblah_gc wrote
My experience with melatonin
Comment on this post
By Dm3
August 30, 2014
Dm3 wrote
Intersting, but unstable.
Ginkgo biloba isn't an SSRI.
Jon  |  September 13, 2014
Comment on this post
By nurseknowledge
August 19, 2014
nurseknowledge wrote
Why Melatonin Isn't The Right Choice
1180views
Comment on this post
By Joey
August 5, 2014
Joey wrote
5 HTP ( 30 days personal experience)
1313views
Comment on this post
By Joe
February 27, 2014
Joe wrote
5 HTP side effects
2804views
I am taking Celexa an SSRI and wanted to taper off so I went from 20mg to now 10mg which sucks for my mood and headaches. I took one pill of the 5HTP to offset my deminished Celexa and waited 15 minutes and ate some ice cream ~ I immediately felt numb, cold sweats, clammy and vomited all of my ice cream, bummer, I'm scared to try another 5HTP pill :(
Jenn  |  August 17, 2014
Comment on this post
By dave riobertson
February 16, 2014
dave riobertson wrote
MELATONIN AND MEMORY LOSS
1675views
Comment on this post
By Sharon
January 15, 2014
Sharon wrote
5HTP and muscle pain and joint pain
1792views
I took 50mg thought I was going to die. It made me so depressed.I hope the depression will go away soon.It has been 2 days now.If it don't go away I am going to the hospital.
margie  |  May 5, 2014
Comment on this post
By Logan Eros
January 7, 2014
Logan Eros wrote
No safe level of 5-htp. . .one last thought
2750views
Comment on this post
By Logan Eros
January 5, 2014
Logan Eros wrote
No safe level of 5htp contd.
2095views
There are many things wrong with this post.

Serotonin syndrome is not caused by an impurity in a supplement. Serotonin syndrome describes a rare state wherein the body makes too much serotonin or doesn't clear it properly, usually because two or more medications affecting serotonin levels have been mixed. This usually involves large doses of something like a cold medicine being taken on top of an antidepressant or recreational abuse of a substance that affects serotonin levels. (Robitussin, f
August 26, 2014
what brand were you using? did you ever look up literature to see if they conducted an assay on your particular brand? 5HTP is a naturally occuring chemical in your body and generally those who are depressed have a deficency. I think you are correct about it being synthetic but it sounds like they were selling something other than advertised. Lastly, eosinophils are a natural type of white blood cell in every human. they can be involved in serious blood disorders but those with eosinophils so
January 27, 2014
Comment on this post
By Logan Eros
January 3, 2014
Logan Eros wrote
No safe level of 5htp
1673views
Definite symptoms of serotonin syndrome, perhaps your body already had a balances serotonin level prior to taking 5htp
J.White  |  August 1, 2014
Comment on this post
By Kjartan
November 12, 2013
Kjartan wrote
5-HTP for sleep
1617views
Comment on this post
By Concern mom
October 6, 2013
Concern mom wrote
Kajungirl1979@yahoo.com
1355views
My son has been kn Clonodine and has night terrors even sleep walk. I am consulting with his doc to wean off and start Melatonin. Its tough no matter what we do. Meds overall I hate.
jmwddd3945@gmail.com  |  June 11, 2014
Comment on this post
By CookieZ
September 2, 2013
CookieZ wrote
5 HTP
1278views
Comment on this post
By Eleanoro
August 27, 2013
Eleanoro wrote
5HTP made me mean
1837views
I've been taking 5-HTP for chronic anxiety disorder (CAD) and depression for about 3 years now
and have never experienced what all the above have. You start out slowing taking 5-HTP, as
indicated on the bottle, and I never exceeded 3 per day. I'm now down to only one per day,
stated on the bottle, and I never took it before bedtime. I don't have anxiety or depression while I'm sleeping, so why would I need to. My doctor paired it with Gaba Calm, so ask your health
care professional if he/
Kay  |  June 21, 2014
I heard that it could cause aggression and road rage type symptoms. I have not experienced this though, and I've been taking it for about 4 weeks. I've actually had more restful sleep since starting it and seem a little more relaxed.
5HTP for Depression  |  June 18, 2014
so that explains my aggressivity..also I had nightmares
Judy  |  February 18, 2014
Comment on this post

What patients are saying about 5-HTP vs. Melatonin

7,156 patient discussions from healthcare websites and blogs
Sleep - I'm sleeping better now that I take 5HTP at about 6...
...- I'm sleeping better now that I take 5HTP at about 6 o'clock & a melatonin tablet at bedtime. it doesn't always work but it's better...
this book, wonderful stuff. the 5htp and melatonin has...
I have this book, wonderful stuff. the 5htp and melatonin has helped me the most. The only thing is who has that kind of dough to keep up with all the supplementation he...
sure if it worked or not.... ZMA: Gave me a weird dreams...
...three: 5-htp: Not really sure if it worked or not.... ZMA: Gave me a weird dreams. I also felt different upon waking. Melatonin: Works f...
and finds that 5HTP is wonderful for guaranteeing you a...
Melatonin is wonderful for a good nights ...melatonin on it's own. Try 5HTP instead you can get ...world and finds that 5HTP is wonderful for guaranteeing you a...
of them. A smidge (50mg) of sustained release 5-htp works...
...makes everything worse. I'm also one of them. A smidge (50mg) of sustained release 5-htp works much better for ...this means my body does a better job of producing optimal melatonin concentrat...
the melatonin helps me fall asleep and the 5-HTP keeps me...
...Try taking 5-HTP in addition to the melatonin. For me, the melatonin helps me fall asleep and...
Then I used 5HTP (which converts to melatonin during...
...many months: I used melatonin to PUT me to sleep. Then I used 5HTP (which converts to melatonin during the night) to put me to sleep. It worked well. You will ...took 2mg Sustain-Release me...
think I do well on the 5htp and melatonin doesn't work...
Thanks. I don't think I do well on the 5htp and melatonin doesn't work for me. I have ordered some Suntheanine brand L-Theanine to see how that will work. I have quit all other dinner supplements...
has done melatonin). 5-htp helped me be less cranky when...
...DS (DS has done melatonin). 5-htp helped me be less cranky ...was born. Gaba and melatonin do nothing for me. Gaba makes DH really emotional (depressed, etc). Melatonin helps DS fall aslee...
effect. I sleep very well w/ just the 5-HTP so I...
...a depressive problem I would avoid Melatonin. I used to take ...However, I wasn't taking 5-HTP at the time ...may counter act the Melatonin's effect. I sleep very well w/ just the 5-HTP so ...
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